Colorectal Cancer
Conditions
Keywords
laparoscopy, laparotomy, elderly
Brief summary
This is a nested cohort study of OAMBP-01. Patients over 70 years old were enrolled into the data-analysis. The purpose of this study was to examine the feasibility and safety of laparoscopic colorectal resection in elderly patients from a single center, and to explore if there are advantages in laparoscopic surgery.
Detailed description
Surgical resection remains the primary treatment for CRC. Despite advancements in surgical techniques, treating elderly cancer patients remains challenging for surgeons. Perioperative risk increases as elderly patients are susceptible to cardiovascular and respiratory diseases. In addition, it has been demonstrated that elderly individuals come with more locally advanced tumor and are more likely to have obstructive or disseminated disease at the time of presentation. In addition, aging diminishes a person's physiological capacity to withstand a major operation. Therefore, surgeons preferred to choose laparotomic colorectal resection to reduce surgical duration and morbidity.. The benefits of laparoscopic colorectal resections over laparotomic surgery have been clearly demonstrated in the general population. However, previous clinical trials comparing surgical approach between laparoscopy and laparotomy restricted the patient's age \<75 years, we have limited information on short- and long-term safety and efficacy of elderly patients underwent laparoscopic colorectal resection. The purpose of this study was to examine the feasibility and safety of laparoscopic colorectal resection in elderly patients from a single center, and to explore if there are advantages in laparoscopic surgery. This is a nested cohort study of OAMBP-01. Patients over 70 years old were enrolled into the data-analysis.
Interventions
Patients over 70 years old underwent laparoscopic or laparotomic colorectal resection were enrolled.
Sponsors
Study design
Eligibility
Inclusion criteria
* 1\. Patient underwent elective laparoscopic or laparotomic colorectal resection for cancer treatment; 2. Patient baseline characteristics and surgical information were available; 3. Patients with complete follow-up data.
Exclusion criteria
* 1\. Emergency surgery for causes including bowel obstruction, bleeding, or perforation; 2. Multiple primary malignancies; 3. Failure to follow-up.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| perioperative complications | 42 days after surgery | include anastomotic leakage, surgical site infection, postoperative ileus, respiratory/urinary tract infection, and deep vein thrombosis (DVT) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| overall survival | 5 years | long term prognosis |
| disease free survival | 5 years | long term prognosis |
Countries
China