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Laparoscopic Colorectal Resection in Elderly

Safety and Effectiveness of Laparoscopic Colorectal Resection in Elderly Patients With Colorectal Cancer

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05563441
Enrollment
360
Registered
2022-10-03
Start date
2015-01-20
Completion date
2023-01-31
Last updated
2023-04-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer

Keywords

laparoscopy, laparotomy, elderly

Brief summary

This is a nested cohort study of OAMBP-01. Patients over 70 years old were enrolled into the data-analysis. The purpose of this study was to examine the feasibility and safety of laparoscopic colorectal resection in elderly patients from a single center, and to explore if there are advantages in laparoscopic surgery.

Detailed description

Surgical resection remains the primary treatment for CRC. Despite advancements in surgical techniques, treating elderly cancer patients remains challenging for surgeons. Perioperative risk increases as elderly patients are susceptible to cardiovascular and respiratory diseases. In addition, it has been demonstrated that elderly individuals come with more locally advanced tumor and are more likely to have obstructive or disseminated disease at the time of presentation. In addition, aging diminishes a person's physiological capacity to withstand a major operation. Therefore, surgeons preferred to choose laparotomic colorectal resection to reduce surgical duration and morbidity.. The benefits of laparoscopic colorectal resections over laparotomic surgery have been clearly demonstrated in the general population. However, previous clinical trials comparing surgical approach between laparoscopy and laparotomy restricted the patient's age \<75 years, we have limited information on short- and long-term safety and efficacy of elderly patients underwent laparoscopic colorectal resection. The purpose of this study was to examine the feasibility and safety of laparoscopic colorectal resection in elderly patients from a single center, and to explore if there are advantages in laparoscopic surgery. This is a nested cohort study of OAMBP-01. Patients over 70 years old were enrolled into the data-analysis.

Interventions

PROCEDURElaparoscopic surgery

Patients over 70 years old underwent laparoscopic or laparotomic colorectal resection were enrolled.

Sponsors

Third Affiliated Hospital, Sun Yat-Sen University
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
70 Years to 100 Years
Healthy volunteers
No

Inclusion criteria

* 1\. Patient underwent elective laparoscopic or laparotomic colorectal resection for cancer treatment; 2. Patient baseline characteristics and surgical information were available; 3. Patients with complete follow-up data.

Exclusion criteria

* 1\. Emergency surgery for causes including bowel obstruction, bleeding, or perforation; 2. Multiple primary malignancies; 3. Failure to follow-up.

Design outcomes

Primary

MeasureTime frameDescription
perioperative complications42 days after surgeryinclude anastomotic leakage, surgical site infection, postoperative ileus, respiratory/urinary tract infection, and deep vein thrombosis (DVT)

Secondary

MeasureTime frameDescription
overall survival5 yearslong term prognosis
disease free survival5 yearslong term prognosis

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026