Multiple Sclerosis
Conditions
Keywords
Multiple Sclerosis, Digital Biomarker, Non-Motor symptoms, Fatigue, Cognition, Depression, Voice Analysis
Brief summary
The investigator will set up a study evaluating vocal biomarkers in people with MS in order to identify persons with non-motor symptoms: depression, cognitive deterioration, and fatigue. Up to now, to the best of the investigator's knowledge, there is no study reporting the use of vocal biomarkers to predict these three non-motor symptoms in people with MS.
Interventions
OTHERVoice analysis
Voice analysis
Sponsors
Audeering GMBH
Biogen
Insel Gruppe AG, University Hospital Bern
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Relapsing MS * Age over 18 * EDSS \< 4.0 * Capability of written informed consent
Exclusion criteria
* Not fluent in german language * Relapse or Steroids per os/intra venous \< 4 weeks prior to examination * KM enhancing lesion in MRI \< 4 weeks prior to examination * Other previous disease affecting the speech * Pregnant patients * Mental disability and not able to understand the protocol and study tasks in german languagePatients with greater physical and cognitive disability or history of major depressive disorder and suicide attempt/suicidal thoughts * Patients with sleep disorders and comorbidities associated with extreme fatigue (e.g., fibromyalgia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of a voice signature that separates between pwMS with and without fatigue | One year |
Secondary
| Measure | Time frame |
|---|---|
| Identification of a voice signature that separates between pwMS with and without cognitive impairment | One year |
| Identification of a voice signature that separates between pwMS with and without depression | One year |
Countries
Switzerland
Outcome results
None listed