Osteoarthritis, Knee
Conditions
Brief summary
To study the effect of anti-inflammatory diet on clinical and biological outcomes in patients with knee osteoarthritis
Detailed description
The investigators would like to evaluate how inflammation occurs in the joints of subjects with osteoarthritis, and identify molecules and bacteria that can predict whether a patients with knee osteoarthritis will have more or less pain . Blood, urine and stool will be evaluated in the laboratory and compared to their own samples after changes in diet. This is an exploratory study, which is meant to gather preliminary data about the quick effects of changes in diet and treatment on molecules in blood/urine and bacteria in stools. These studies can provide clues to the cause of disease and might ultimately lead to new therapies.
Interventions
DIETARY_SUPPLEMENTITIS diet
anti-inflammatory (ITIS) diet for 28 days
Sponsors
University of California, San Diego
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients diagnosed of Knee Ostoeaarthritis * without changes in treatment in the last 3 months
Exclusion criteria
* food allergies * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of baseline pain measured by visual analogue scale (0-10) after 28 days | 28 days | Change of baseline pain measured by visual analogue scale (0-10) after 28 days, being 0 no pain, and 10 the worse outcome |
Countries
United States
Contacts
Primary ContactMonica Guma, MD, PhD
Outcome results
None listed