Brain Oxygenation Marker for Cognitive Function in Healthy Adults

Identification of a Brain Oxygenation Marker for Cognition Using Functional Near Infrared Spectroscopy in Healthy Adults

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05559034

Enrollment

Registered

2022-09-29

Start date

2022-09-06

Completion date

2022-12-15

Last updated

2023-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mental Fatigue

Keywords

Cortical tissue oxygenation, Cognition, Time-on-task, Functional Near Infrared Spectroscopy

Brief summary

This study aims to identify a cortical oxygenation marker for cognitive function using functional Near Infrared Spectroscopy in healthy adults.

Detailed description

This study will aim to establish a model between the cortical oxygenation and cognitive performances given modulations by experimental conditions including the cognitive workload and the time-on-task, and individual variabilities such as the age or the gender.

Interventions

BEHAVIORALCognitive intervention

This is a cognitive intervention consisting in the repetition according to three blocks, of cognitive tasks (Stroop and N-back tasks) at variating workload levels (low, middle and high levels). Each cognitive task will be presented for each workload level during three minutes.

Study design

Observational model

OTHER

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

25 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

1. Males and Females 25-45 years old 2. BMI between 18.5 kg/m2 and 29.9 kg/m2 3. Conditions for study procedure compliance: * Willing and able to sign an informed consent form * Be fluent in English (self-reported C1 or C2 English level) * Be able to provide a cortical oxygenation signal (based on feasibility to fix the measurement device on the scalp, which can be altered by hair thickness) * Be dominant right-handed * Have a normal or corrected-to-normal vision * Be expected to comply with the protocol

Exclusion criteria

The project

Design outcomes

Primary

Measure	Time frame	Description
Modulation of cortical tissue oxygenation	Day 1	Cortical tissue oxygenation parameters will be given by the concentration changes of oxygenated and deoxygenated hemoglobins measured with functional Near Infrared Spectroscopy.

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026