Bone-To-Implant Contact At 4- And 6-Week Healing Stages in Implants With Different Surfaces.

Bone-To-Implant Contact At 4- And 6-Week Healing Stages in Implants Having Either Machined, SLA Medium Roughness, Nanostructured Calcium-Incorporated or Plasma Reactivated Nanostructured Calcium-Incorporated Surface: A Histologic Study.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05558800

Enrollment

Registered

2022-09-28

Start date

2018-01-01

Completion date

2022-07-30

Last updated

2023-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Implant Geometry

Brief summary

Objective: Implant surface topography is a key element in achieving osseointegration. Nanostructured surfaces have shown promising results in accelerating and improving bone healing around dental implants. The main objective of the present clinical study is to compare, at 4 and 6w, bone-to-implant contact in implants having either machined surface (MAC), SLA medium roughness surface or a Nanostructured Calcium-Incorporated surface (XPEED®). Thirty five mini-implants with 3 different surface treatments (XPEED® (n=16) - SLA (n=13) - Machined (n=6)), were placed in the posterior maxilla of 11 patients then retrieved at either 4 or 6w in a randomized split-mouth study design.

Interventions

PROCEDUREImplant placement

Implant placement with different surface types

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* • Height of the residual bone crest in the programmed implant site ≥ 9 mm and thickness ≥ 7mm. * Availability, in each sector, of sufficient mesio-distal space allowing placement of 2 standard-sized implants and at least 2 mini-implants (3.5x8.5mm) for retrieval. * Healed bone crest (≥ 3 months elapsed after extraction or tooth loss). * Age \> 18 years. * Ability to examine and fully understand the study protocol.

Exclusion criteria

* • Myocardial infarction within the past 6 months. * Poorly controlled diabetes (HBA1c \> 7.5%). * Coagulation disorders. * Radiotherapy to the head/neck area within the past two years. * Present or past treatment with intravenous bisphosphonates. * Immunocompromised patients. * Psychological or psychiatric problems. * Alcohol or drug abuse. * Poor oral hygiene and motivation (full mouth plaque score \> 30% and/or full mouth bleeding score \> 20%). * Uncontrolled periodontal disease.

Design outcomes

Primary

Measure	Time frame	Description
Bone to implant contact	4 weeks healing period after implant placement	Histology technique on specimen retrieved containing mini-implants and bone surrounding it

Countries

Lebanon

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026