Are Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Systemic Immune Inflammation Score Values Indicators for Postoperative Pain?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05558553

Enrollment

Registered

2022-09-28

Start date

2022-09-18

Completion date

2022-09-24

Last updated

2023-11-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain Status of Patients Who Underwent Elective Laparoscopic Cholecystectomy

Keywords

Laparoscopic cholecystectomy, posoperative pain, neutrophil lymphocyte ratio, platelet lymphocyte ratio, systemic immune inflammation score, tramadol consumption

Brief summary

Postoperative pain status of patients who underwent elective laparoscopic cholecystectomy.

Detailed description

Subject Researched: Postoperative pain is a result of the inflammatory response to surgical trauma. Local inflammatory mediator response triggered by surgical incision, dissection, retraction, etc. causes an increase in nociceptor sensitivity and hyperalgesia, resulting in the perception of postoperative pain. With the acute phase response caused by surgical trauma, tissue damage is brought under control, infection is limited and the healing process begins. During the inflammatory response, the level of leukocytes in the blood also changes. Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR) and Systemic immune inflammation score (SII) are inexpensive and easily accessible biomarkers calculated from routine hemogram parameters and shown to be helpful in disease investigations and evaluation of treatment response. In this study, the relationship between biomarkers and postoperative pain status due to surgery will be investigated

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Inclusion criteria

1. Patients aged 18-75 years who underwent elective laparoscopic cholecystectomy. 2. Patients with ASA status1-2-3

Exclusion criteria

1. Emergency operated patients 2. Patients switched to open surgery 3. Patients allergic to tramadol 4. Those allergic to paracetamol 5. Those allergic to tenoxicam 6. Patients who cannot use the patient-controlled analgesia device 7. Those with hematological disorders 8. Those receiving immunosuppressive therapy 9. Those with inflammatory disease 10. Those with gastrointestinal tumors 11. Those with rheumatic disease 12. Those with uncontrolled diabetes 13. Those with chronic organ failure 14. Those who use corticosteroids 15. Opioid users 16. Those who have recently had an attack of cholecystitis, pancreatitis

Design outcomes

Primary

Measure	Time frame
postoperative analgesic consumption	24 hours

Secondary

Measure	Time frame	Description
postoperative pain score	24 hours	NRS 0-10 point

Countries

Turkey (Türkiye)

Outcome results