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The Social Regulation of Threat-related Vigilance and Arousal

Effects of Trauma and Discrimination on the Social Regulation of Threat-related Vigilance and Arousal

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05558527
Enrollment
45
Registered
2022-09-28
Start date
2025-12-18
Completion date
2029-12-01
Last updated
2026-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxiety, Discrimination, Racial, Emotion Regulation, Hypervigilance, Psychological Trauma, Historical, Social Interaction

Keywords

psychological trauma, ethnoracial discrimination, hypervigilance, anticipated threat, social emotion regulation, social touch

Brief summary

This study will examine the effects of social support on threat vigilance and arousal using eye tracking. We will also test the moderating effects of trauma and discrimination history.

Detailed description

Both interpersonal trauma (IPT) and ethno-racial discrimination amplify risk for hyper-arousal symptoms of posttraumatic stress disorder (PTSD), but the mechanism of this effect is unclear. Prior research suggests that social support plays an important role in regulating emotional responses, a process called social emotion regulation. This study will test whether a history of IPT and/or ethno-racial discrimination influence the social regulation of arousal and vigilance. Social regulation will be tested by contrasting responses under conditions with and without social support.

Interventions

BEHAVIORALsocial support

social support is provided in the form of social touch (hand holding)

Sponsors

University of Nevada, Reno
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

* In a stable romantic relationship for 6 months or more * Normal vision or corrected-to-normal vision * Fluent in English

Exclusion criteria

* If vision is corrected-to-normal, needs to use hard contact lenses, bifocal contact lenses, or glasses * Experienced a traumatic event within the past 4 weeks

Design outcomes

Primary

MeasureTime frameDescription
Vigilance Related Eye Movements - Number of Eye FixationsCollected from minute 15 to minute 45 of study participation, approximatelyParticipants will view 15 pictures of natural environmental scenes for 10 seconds per image. We will use an eye tracker to examine the number of eye fixations per scene. A greater number of fixations during the 10 second presentation of a scene would indicate greater vigilance.
Vigilance Related Eye Movements - Visual ScanningCollected from minute 15 to minute 45 of study participation, approximatelyParticipants will view 15 pictures of natural environmental scenes for 10 seconds per image. We will use an eye tracker to examine the proportion of the scene that they look at (fixate on) out of approximately 80 possible sectors. A greater proportion of the scene they fixate on would indicate greater vigilance.
Threat-Related Physiological Arousal - Pupil DilationCollected from minute 45 to minute 75 of study participation, approximatelyParticipants will view a series of visual cues (either an 'X' or an 'O') where an 'X' signals a possible (20% probability) aversive auditory stimulus (human scream). We will examine pupil dilation during the task in order to measure arousal in response to uncertain threat. We will calculate average pupil dilation during the wait period after threat cues (X) and after safety cues (O). We will subtract average pupil dilation after safety cues from threat cues to create an index of threat-related arousal. Greater pupil dilation (for threat minus safety cues) would indicate greater threat-related arousal.

Countries

United States

Contacts

CONTACTKylie Baer, MS
kyliebaer@unr.edu(775) 682-8145
CONTACTCynthia L Lancaster, PhD
cynthialancaster@unr.edu(775) 682-8145
PRINCIPAL_INVESTIGATORCynthia L Lancaster, PhD

University of Nevada, Reno

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 14, 2026