Cancer, Overweight and Obesity
Conditions
Brief summary
This is a pilot feasibility study of an investigation of the influence of excess adiposity on cardiorespiratory fitness (CRF), insulin-like growth factor-1 (IGF-1), and metabolic responses to a standardized aerobic exercise program in cancer survivors. This investigation attempts to isolate the influence of adiposity on these responses. We will enroll overweight, obese, and normal weight cancer survivors with a primary diagnosis of breast, prostate, or colorectal cancer who have completed all cancer-related treatment. Participants will engage in a 15-week aerobic exercise intervention with pre- and post-intervention assessments.
Interventions
BEHAVIORALAerobic Exercise
A 15-week standardized aerobic exercise intervention. * Frequency: 5 days/wk (2 supervised) * Intensity: 50-59% heart rate reserve * Time: 40 min/session (ramp up from 25-40 during first 4 weeks) * Type: Aerobic exercise (e.g. treadmill, walking/jogging, cycling, elliptical)
Sponsors
University of Colorado, Denver
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Single-arm feasibility pilot
Eligibility
Sex/Gender
ALL
Age
21 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* Primary cancer diagnosis of breast, prostate, or colorectal cancer * Completion of all cancer-related treatment \> than 6 months prior and \< 5 years prior to enrollment * Ability and willingness to participate in a supervised exercise program * All participants will be required to obtain a signed physician clearance to participate in exercise form prior to enrollment
Exclusion criteria
* Presence of a secondary active cancer diagnosis or metastatic disease * Any current cancer treatment (including hormonal treatment) or planned cancer treatment in the next 5 months * Greater than 100 min of self-reported regular exercise per week * BMI \< 18.5 (underweight) * Any significant metabolic condition, such as diabetes. Individuals with pre-diabetes or metabolic syndrome will not be excluded, but this information will be recorded. * Any medical condition that would impact the safety of, or participation in, an exercise program or exercise testing, including: * Orthopedic conditions such as advanced osteoarthritis, mobility-limiting amputations or chronic injuries, or mobility-limiting acute orthopedic injuries * Advanced rheumatoid arthritis or chronic widespread pain conditions such as fibromyalgia * Pulmonary conditions such as chronic obstructive pulmonary disease, emphysema, or interstitial lung disease * Known cardiovascular disease, uncontrolled hypertension, or new cardiac event within the past 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Recruitment | up to 12 months | Number of participants joining the study per month |
| Study Adherence | up to 12 months | Percentage of participants completing pre- and post-intervention assessments |
| Intervention Adherence | 15 weeks | Average percentage of prescribed exercise sessions completed by participants |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum IGF-1 | Baseline, Week 15 | Collected via venipuncture |
| Estimated VO2max | Baseline, Week 15 | Maximal oxygen consumption estimated from a 3 minute step test (Tecumseh Step Test) |
| Total visceral adiposity | Baseline, Week 15 | Collected with dual-energy x-ray absorptiometry |
Countries
United States
Outcome results
None listed