The Supraspinal Control of Lower Urinary Tract Function in Patients with Orthotopic Sigmoid Neobladder.

Neuroimaging Study of Supraspinal Control of Lower Urinary Tract Function in Patients with Orthotopic Sigmoid Neobladder.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05558111

Enrollment

Registered

2022-09-28

Start date

2022-06-01

Completion date

2025-06-01

Last updated

2024-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthotopic Neobladder

Keywords

Orthotopic neobladder, Functional magnetic resonance imaging, Neuroimaging Study, Lower urinary tract function, Bladder cancer

Brief summary

Orthotopic sigmoid neobladder surgery is one of the ideal urinary diversion methods after radical cystectomy.In recent years, functional imaging studies have revealed brain regions related to urinary system function, but brain activity of lower urinary tract function in neobladder patients is still unclear.The aim of this study is to explore the brain activity of urination intention and self-controlled urination behavior in patients with orthotopic sigmoid neobladder by task-state functional magnetic resonance imaging (fMRI).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

1. Being right-handed; 2. 3 months or more after operation; 3. No contraindications to fMIR examination; 4. Voluntarily sign informed consent.

Exclusion criteria

1. History of bladder radiotherapy; 2. History of prostate cancer; 3. Suffering from diseases affecting abdominal pressure; 4. History of abnormal brain anatomy, craniocerebral surgery, craniocerebral tumor, and craniocerebral radiotherapy; 5. History of mental disorders, Parkinson's disease, Alzheimer's disease, epilepsy, cerebral infarction, cerebral hemorrhage; 6. Claustrophobia or carrying metal implants that are not suitable for fMRI examination; 7. Diseases affecting lower urinary tract function (such as spinal cord injury, diabetic peripheral neuropathy, etc.); 8. Urethral stricture; 9. Refusing to sign the informed consent form for clinical projects; 10. Other conditions that were not suitable for inclusion according to the investigator's judgment.

Design outcomes

Primary

Measure	Time frame	Description
The location of brain functional activation areas	3 months	Areas of the brain where excitation or inhibition occurs in fMRI images
The peak T-value size of the activation region	3 months	Peak T values of activated or inhibited regions of the brain in fMRI images

Countries

China

Contacts

Primary ContactChunxiao Liu

liuchx888@163.com13302296795

Backup ContactYuanxing Huang

852691657@qq.com13826196384

Outcome results