Testicular Torsion

Is There a Toll-like 4 Receptor Relationship in Patients With Testicular Torsion?

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05558072

Enrollment

Registered

2022-09-28

Start date

2012-01-01

Completion date

2022-04-30

Last updated

2022-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Testicular Torsion and TLR 4 Was Investigated

Keywords

testicular torsion,, Toll-like receptors (TLR),, child, newborn, adolescent

Brief summary

Background: Testicular torsion is a scrotal emergency that results in impaired blood supply to the testis and ischemia of the testis as a result of the rotation of the spermatic cord around itself. The etiology of testicular torsion is not clear, but various predisposing factors are responsible for the occurrence of testicular torsion. Recently, with the discovery of Toll-Like Receptors (TLRs), new horizons have been opened in the field of innate immune system-related diseases. Objective: To mediate the relationship between testicular torsion and TLR4 receptors. Material-Method: Testicular specimens of patients who developed testicular ischemia after testicular torsion and underwent orchiectomy between 2012-2022 were reached. A study of TLR 4 receptors was performed in these testicular specimens. The patients were divided into two groups according to their ages newborns and adolescents.

Detailed description

Analysis of 32 newborns and 32 adolescents between the ages of 14 and 16 (mean age was 15.17 ± 0.98) testicular tissue lysate using Toll-Like Receptor antibody 4 (TLR4) ELISA (Enzyme-Linked ImmunoSorbent Assay). Toll-like receptor 4 is a transmembrane protein that in humans is encoded by the TLR4 gene. Its activation leads to the production of inflammatory cytokines.

Interventions

GENETICToll-like receptor 4

Toll-like receptor 4

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

MALE

Age

0 Days to 16 Years

Healthy volunteers

Yes

Inclusion criteria

testicular torsion * newborn, adolescent,

Exclusion criteria

* orchitis, urinary infection, trauma,

Design outcomes

Primary

Measure	Time frame	Description
Toll-like receptor 4 positives or negative	10 years	testicular torsion

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026