Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease

Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease; Udall Project 2 Aims 1 & 2

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05557864

Enrollment

Registered

2022-09-28

Start date

2016-08-25

Completion date

2026-12-31

Last updated

2026-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease

Brief summary

This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practice by providing a potential strategy to these medically intractable symptoms.

Interventions

DEVICEDeep Brain Stimulation

Pallidal Deep Brain Stimulation

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to 89 Years

Healthy volunteers

Inclusion criteria

* diagnosis of idiopathic PD * have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN) * Existing 7T brain imagery

Exclusion criteria

* history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs * other significant neurological disorder * history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR) * post-operative complications or adverse effects

Design outcomes

Primary

Measure	Time frame	Description
Changes in the combined elastic, viscous and inertial resistance across conditions will be assessed by integrating the resistive torque	3 weeks	Average movement rate and amplitude for each tone rate-movement amplitude interval. The amount of variability in angular displacement and velocity will be calculated using the root mean square of the zero mean signal. The structure of the variability will be calculated using the sample entropy function. In addition, we will quantify the number and duration of movement festination or freezing episodes.

Countries

United States

Contacts

CONTACTColum MacKinnon, PhD

cmackinn@umn.edu

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026