Cognitive Function
Conditions
Keywords
Transcranial Magnetic Stimulation, TMS
Brief summary
The purpose of this study is to determine optimal task design parameters for the measurement of transcranial magnetic stimulation (TMS) effects on cognition.
Detailed description
Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that relies on rapidly changing magnetic fields to influence neuronal firing rates. TMS can be used to temporarily inhibit or enhance the firing of populations of neurons located in the cerebral cortex. TMS-induced cortical inhibition versus enhancement is increasingly being used as a tool for exploring brain-behavior relationships and for improving cognitive functioning in people experiencing cognitive deficits due to neuropsychiatric illness (e.g., dementia and schizophrenia). However, important and unresolved methodological issues in this field concern the optimal design of cognitive tasks for TMS stimulation protocols. The purpose of this study is to determine optimal design protocols for online TMS studies of cognitive processes involved in attention, learning, and memory. Research participants will complete cognitive tasks while active versus sham (i.e., non-stimulating) TMS is applied to the brain. A factorial design will be used to determine the combination of task and TMS parameters (i.e., device settings) that produce the most robust and reliable behavioral effects.
Interventions
DEVICETranscranial Magnetic Stimulation
Transcranial Magnetic Stimulation (TMS) is a noninvasive method for stimulating neurons (axons not cell bodies) in the brain.
Sponsors
Colorado State University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Masking description
Participants are blinded to TMS therapy, sham control
Intervention model description
Mechanistic study of impact of transcranial magnetic stimulation (TMS) on cognitive function.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Right-handed * Fluent in English
Exclusion criteria
* History of seizures or epilepsy * Family history of epilepsy * Significant medical or neurological diagnoses * History of common headache or migraine * History of common or recent syncope * History of moderate/severe, multiple mild, or past 12 months head injury * History of psychiatric, psychological, or neurodevelopmental disorder * History of alcohol or recreational drug abuse or dependence * Current visual or hearing difficulties that interfere with cognitive testing * History of cochlear implants * Current pregnancy * History of metal in the head or neck (except braces and fillings) * Current non-removable piercings in the neck or head * History of implanted neurostimulator * History of cardiac pacemaker or intracardiac lines * History of medication infusion device * Current use of medications that increase the excitability of the brain * History of problems with TMS or MRI procedures * History of EEG for suspected epilepsy * Alcohol or recreational drug use in the 48 hours prior to TMS * Inadequate sleep in the 48 hours prior to TMS * Headache or feeling faint in the 24 hours prior to TMS.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sternberg Memory Task (Accuracy) | Single study appointment. 1 hour. There will be no follow up. | Mean item accuracy on a computerized Sternberg memory task. |
| Sternberg Memory Task (Reaction Time) | Single study appointment. 1 hour. There will be no follow up. | Mean item reaction time on a computerized Sternberg memory task. |
Countries
United States
Contacts
CONTACTMichael Thomas, PhD
Outcome results
None listed