Complication, Liver Diseases
Conditions
Keywords
liver resection, complication, risk factor, machine learning, hepatolithiasis
Brief summary
Postoperative complications seriously affect the recovery of patients undergoing hepatectomy. Identifying risk factors and develop predictive models of complications for patients with hepatolithiasis undergoing hepatectomy is important for clinical practice.
Detailed description
Along with the change of lifestyle and dietary habits, many people are diagnosed with hepatolithiasis that is especially prevalent in Asia. Liver resection remains the favorable curative therapy for hepatolithiasis with a relatively low recurrence rate. Although there have been great improvements in surgical techniques and perioperative management, postoperative complications remain commonplace and seriously threat the recovery of patients undergoing hepatectomy. Therefore, it is important to identify risk factors of complications to improve the overall prognosis of patients. We want to collect the clinical information of patients with hepatolithiasis undergoing hepatectomy, including demographic data , laboratory index, histological features and postoperative complications. Patients are followed up at a interval of 3 month after treatment, and the survival data and recurrence rate are recorded. Then the relationship between clinical data and short-term outcomes after surgery are explored. Then models based on clinical features are developed to predict short-term outcomes after hepatectomy.
Interventions
DIAGNOSTIC_TESTradiological evaluation
All patients undergoing hepatectomy receive imaging evaluation and laboratory test before and after surgery to define clinical parameters. diseases
Sponsors
Eastern Hepatobiliary Surgery Hospital
The First Affiliated Hospital of Zhejiang Chinese Medical University
Qilu Hospital of Shandong University
First Affiliated Hospital of Wenzhou Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* pathologically diagnosed hepatolithiasis * without malignancies * receiving liver resection * Eastern Cooperative Oncology Group performance status (ECOG-PS) 0-2 * Child-Pugh score of ≤7 * complete clinical and follow-up information * age between 18-80 years old
Exclusion criteria
* with malignancies * receiving other treatments * Eastern Cooperative Oncology Group performance status (ECOG-PS) \>2 * Child-Pugh score of \>7 * incomplete clinical data * lost to follow up * age \<18 years old or \>80 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Complications | 3 months | Postoperative complications and mortality are recorded according to the Clavien-Dindo classification system |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Recurrence of hepatolithiasis | 1 year | Patients were followed-up at an interval of 3 months and recurrence of hepatolithiasis is evaluated by radiological methods. |
Countries
China
Outcome results
None listed