Endometriosis
Conditions
Brief summary
78 endometriosis patients presented with infertility were clinically examined and the diagnosis was assured by US imaging. The study also included 11 control fertile women free of gynecological problems as a control for lab tests. Patients and controls gave blood samples for lab investigations. All patients underwent diagnostic abdominal laparoscopy under general anesthesia for disease staging. Quantitative determination of expression levels of genes of microRNA-125b-5p and 203a was conducted using qRT-PCR.
Interventions
PROCEDURElaparoscopic examination
laparoscopic examination for staging of endometriosis
DIAGNOSTIC_TESTBlood sampling
Blood sample to detect endometriosis
Sponsors
Tanta University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
22 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients who presented clinical pictures suggestive of EM disease
Exclusion criteria
* Patients with previous pelvic or abdominal surgery that may hinder the laparoscopic examination, * patients who were suspicious of having malignancy elsewhere in the body region, * pregnant women, * patients who had diabetes mellitus, * body mass index (BMI) of \>30 kg/m2, coagulopathies, and autoimmune disorders.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Validity of Plasma expression level | two weeks | the diagnostic validity of estimation of plasma expression levels of MiR-125b-5p and 203a for diagnosis and staging of endometriosis. |
Countries
Egypt
Outcome results
None listed