Embryo Implantation, Fertility Issues, Frozen Embryo Transfer
Conditions
Keywords
Embryo, Frozen embryo transfer, Progesterone, Embryo implantation
Brief summary
Endometrin is a progesterone supplement prescribed during in vitro fertilization (IVF) for preparation for embryo transfer. The usual dose of Endometrin is 100 mg two to three times per day in the form of an effervescent tablet to be inserted vaginally. The purpose of this research project is to evaluate the dose response of the Endometrin when determined based on the blood level of progesterone on the day of the FET. According to the literature, a predefined level of progesterone in the blood should be reached in order to have favorable conditions for pregnancy. The hypothesis being that a woman with low progesterone levels would benefit from a dose of Endometrin of 600 mg (200 mg 3x/day) to decrease the risk of miscarriage and improve the chances of pregnancy. Women with adequate progesterone levels according to the literature, would continue with the standard dose of progesterone prescribed at clinique ovo which is 300 mg (100 mg 3x/day). PIBF (Progesterone Induced Blocking Factor) levels, a protein found in the blood that could also predict pregnancy outcomes in women using IVF will also be looked at.
Interventions
DRUGProgesterone Effervescent Vaginal Tablet
On the day of Frozen Embryo Transfer (FET), women will have a blood test to determine progesterone levels. Depending on the result of progesterone level, the participant will be assigned to either the Endometrin 100 mg TID dose or the Endometrin 200 mg TID dose
Sponsors
Ferring Pharmaceuticals
Clinique Ovo
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Single centre, prospective, open label study
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 42 Years
Healthy volunteers
No
Inclusion criteria
* Women 18-42 years of age * Normal uterine cavity (according to treating physician) * FET substituted cycle prescribed * First or second cycle of FET * Adequate endometrial pattern (triple layer) and thickness (\>7 mm) after adequate standard endometrial preparation in artificial cycle
Exclusion criteria
* Any uterine abnormalities confirmed by treating physician making participant unable to proceed with FET * Patients with personalized FET according to the endometrial receptivity assay tests * Previous allergic reactions to progesterone or any of the ingredients of Endometrin * Severe hepatic dysfunction or disease * Known or suspected breast cancer or genital tract cancer * Known active arterial or venous thromboembolism or severe thrombophlebitis or cerebro-vascular disease, or a history of these events * Diagnosed porphyria * Undiagnosed abnormal vaginal bleeding * Known missed abortion or ectopic pregnancy * Recurrent pregnancy loss excluding biochemical pregnancies * Hypersensitivity to Acetylsalicylic acid (ASA), salicylates, non-steroidal anti-inflammatory drugs (NSAIDs), analgesics, antipyretics or other ingredients in the product or component of the container * Acute gastrointestinal ulcer, history of gastrointestinal ulcers and hemorrhagic diathesis * Active or severe renal disease, or congestive heart failure * History of asthma induced by salicylates or other NSAIDs * Use of methotrexate at doses of 15mg/week or more * Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluate the ongoing pregnancy rate | 6 to 8 weeks after Frozen Embryo Transfer | Viability ultrasound |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluate the miscarriage rate | 6 to 8 weeks after Frozen Embryo Transfer | Viability ultrasound |
| Evaluate progesterone levels | Before embryo transfer and 10 days after embryo transfer | Progesterone levels will be tested at two different times |
| Evaluate the rate of biochemical pregnancy | 10 days after frozen embryo transfer | Serum pregnancy test to measure Beta Human Chorionic Gonadotropin (BhCG) levels |
Other
| Measure | Time frame | Description |
|---|---|---|
| Blood test to evaluate the prevalence of PIBF | Before embryo transfer and 10 days after embryo transfer | Progesterone Inducing Blocking Factor (PIBF) has been found to to have an important part in creating a welcoming environment for the embryo |
Countries
Canada
Outcome results
None listed