Aortic Diseases, Arterial Disease, Thrombosis
Conditions
Keywords
Complex aortic endovascular repair, Arterial recanalization, Deep veinous recanalization, Anti Xa, LR-ACT, Heparin, Endovascular procedures
Brief summary
Activated clotting time (ACT) is currently recommended to monitor high concentrations heparin anticoagulation. ACT-LR was specifically designed to measure the activity of low dose of heparin used during endovascular surgery. The correlation between ACT-LR and Anti Xa activity which is considered as the gold standard seems to be debated. Few studies in literature had shown controversial results. These studies were conducted in patients who underwent open as endovascular surgery. However, the ACT monitoring is not recommended in open surgery. In addition, heparin administration protocols are not described and specific to each centre. In this study investigators want to study the correlation between LR-ACT and anti Xa after introducing a heparin protocol during complex endovascular procedures.
Interventions
BIOLOGICALAnti Xa activity measurement.
Arterial blood samples of 3cc will be taken during the procedure at each ACT. Blood samples will be sent to the lab for anti Xa activity measurement.
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 ans * Weight ≥ 37,5 kg * Patients operated for * complex endovascular aortic aneurysm repair * deep vein recanalization * complex arterial revascularization (TASC D lesions) * Patient informed of the study details and who didn't opposed to participate in this research
Exclusion criteria
* Known allergy to heparin * Known hepatic insufficiency with repercussion on coagulation * Thrombocytopenia * Known hemostasis disorders * Anemia defined HB\<8 g/L * Pregnant women * Persons deprived of their liberty by a judicial or administrative decision * Persons subject to psychiatric care * Persons admitted to a health or social establishment for purposes other than research * Adults subject to a legal protection measure (guardianship, curatorship)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between ACT (second) realized in operative room and Anti Xa activity (UI/ml) results provide by the lab. | During surgery - 1 day | Following the heparin administration protocol, each ACT measurement will be associated to a blood samples for anti Xa activity measurement. Retrospectively, anti Xa results will be analyze and compare to ACT value which will be report in the operative report. The blood samples will be taken in operative room during endovascular procedures as defined in the protocol. |
Countries
France
Outcome results
None listed