Left Bundle Branch Pacing
Conditions
Keywords
Left Bundle Branch Pacing
Brief summary
This is a prospective, single-center study of patients with an indication for ventricular pacing who attempted LBBP without electrophysiology recording system (EP system).
Detailed description
Patients who meet the inclusion and exclusion criteria will be enrolled into the study. In the study, the implanter was blinded to EP system, only refer to ECG monitoring. The transition of QRS morphology from S-LBBP (or LVSP) to NS-LBBP, abrupt shortening of Stim-LVAT in lead V5, combined with LV septal-derived PVCs and obvious LBB potential in pacing system analyzer were recorded to help the implanter confirm LBB capture. Meanwhile, the technician recorded the data by EP system and evaluated the consistency of the judgment. The primary endpoints included the success rate, procedure-related information, parameters and complications during 3-month follow-up.
Interventions
Left bundle branch pacing by a CRT device or dual-chamber pacemaker through the pacing lead at left bundle branch region
Sponsors
First Affiliated Hospital of Wenzhou Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* (1) requiring ventricular pacing; (2) older than 18 years; (3) signed informed consent.
Exclusion criteria
* (1) acute anterior myocardial infarction; (2) intraventricular conduction delay (IVCD); (3) ventricular septal hypertrophy (end-diastolic thickness over 15 mm).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Successful rate | Immediate Postoperative | Success rate of left bundle branch pacing without EP system |
| Judgment coincidence rate | Intraoperative | Coincidence rate between the judgment made by the operator through ECG and PSA with EP system. |
| Intraoperative complications | Immediate Postoperative | Intraoperative complications were recorded |
| Postoperative complications | 3 months | Postoperative complications were recorded |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Procedure duration | Immediate Postoperative | Total time required for operation |
| Change of impedance(Ω) from immediate postoperative | 3 months | Impedance during unipolar pacing |
| Fluoroscopy time | Immediate Postoperative | Intraoperative time of radiation use |
| Change of threshold(V/0.5ms) from immediate postoperative | 3 months | Threshold for capturing left bundle branch during unipolar pacing |
| Change of LVEF(%) from baseline | 3 months | LVEF changes before and after surgery |
Countries
China
Contacts
Primary ContactWeijian Huang, MD
Backup ContactLan Su, MD
Outcome results
None listed