Cognitive Impairment, Gastrointestinal Neoplasms
Conditions
Keywords
Gastrointestinal Neoplasms, Cognitive Impairment, Vitamin D
Brief summary
To explore the effect of different doses of vitamin D drugs on gastrointestinal cancer cancer-related cognitive impairment, so as to provide reference and basis for the clinical use of our cognitive function surgery nursing plan for patients with gastrointestinal cancer.
Detailed description
To determine the incidence of postoperative cognitive dysfunction in patients with gastrointestinal tumors to determine the influencing factors of postoperative cognitive dysfunction in patients with gastrointestinal tumors. The characteristics of perioperative cancer-related cognitive impairment in patients with gastrointestinal tumors were analyzed by monitoring preoperative and postoperative FACT-COG cognitive scale connection test (Hua-Shan-version auditory word learning test) DSST digit symbol test gaffes detection task and hematology indexes, such as observation and analysis of the interference pattern of supplement vitamin D preparation postoperative hospital stay in patients with gastrointestinal tumor short-term cognitive impairment related to cancer, in order to reduce the incidence of complications and hospitalization days, improve cognitive function in patients with gastrointestinal tumor surgery, and improve the quality of nursing.
Interventions
DRUGVitamin D
The patients were given vitamin D supplementation 48 hours after surgery, and the two groups were given different doses of vitamin D supplementation until the postoperative discharge criteria were met. To scientifically evaluate the application effect of early postoperative vitamin D intervention in the improvement of perioperative cognitive function in patients with gastrointestinal tumors.
Sponsors
Subei People's Hospital of Jiangsu Province
Yangzhou University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with gastrointestinal tumors diagnosed by gastroscopy and histology and their family members * Elective surgery * Education level in primary school or above * Be able to fill in the questionnaire alone or under the guidance of the researcher * Informed consent and voluntary participation in this study
Exclusion criteria
* Patients with cognitive impairment (illiteracy less than 17 points, primary school less than 20 points, secondary school or above less than 24 points) or previous history of cognitive impairment, dementia and delirium confirmed by MMSE examination before surgery * Patients with life-threatening acute and chronic diseases * Patients with eye or ear diseases leading to rapid loss of hearing or vision without AIDS * Patients who have taken drugs related to improving cognitive function or drugs for psychiatric disorders * Patients who cannot take care of themselves or are physically disabled and unable to perform neurological function tests * Intraoperative hypoxemia (blood oxygen saturation \< 94％) more than 10 minutes * Patients who quit or died due to non-cooperation or emergency
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive function | Eight days after the surgery | Fact-cog Cognitive Scale.The higher the score, the better the cognition. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sleep | Eight days after the surgery | Pittsburgh sleep quality index.The overall score ranges from 0 to 21, with a score of 0 to 5 indicating good sleep quality,6 to 10 indicating fair sleep quality,11 to 15 indicating fair sleep quality, and 16 to 21 indicating very poor sleep quality. |
| Cancer related fatigue | Eight days after the surgery | Cancer Fatigue Scale. The total score ranges from 0 to 15, and 4 is considered frailty. |
| Asthenia | Eight days after the surgery | Groningen Frailty Indicator. The total score ranges from 0 to 15, and 4 is considered frailty. |
Countries
China
Contacts
Primary ContactDaorong Wang, Professor
Outcome results
None listed