Obsessive-Compulsive Disorder
Conditions
Keywords
obsessive-compulsive disorder, natural psychotherapy
Brief summary
explore objective indicators of the efficacy of natural psychotherapy in the treatment of disorders such as obsessive-compulsive disorder
Detailed description
1. To evaluate the cognitive function, Cognitive control, emotion and other aspects of neurosis patients, and to understand and master the cognitive behavior indicators of this population. 2. Investigate the pathological mechanism of neurotic patients from the aspects of EEG/fMRI and biology. 3. To investigate the therapeutic effect of natural psychotherapy on cognitive impairment and related mood, sleep and symptom intervention in neurotic patients. In order to achieve the symptoms of neurosis patients, cognitive impairment and related mood and sleep intervention and promotion, while providing a scientific basis for neurosis rehabilitation.
Interventions
BEHAVIORALMental Health Education
Mental Health Education Seminar
BEHAVIORALNatural Psychotherapy
Natural psychotherapy is based on Morita therapy and is a psychotherapy that fully reflects the characteristics of Chinese culture, taking into account the Chinese cultural background and actual clinical characteristics.
Sponsors
Beijing HuiLongGuan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Masking description
The patient was assigned to either the intervention group or the control group, but the control group would also receive treatment after a two-month waiting period. Therefore, the patient was only informed whether they would be participating in the first or second intervention.
Eligibility
Sex/Gender
ALL
Age
15 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* were between 16 and 55 years old; * were diagnosed with OCD by an experienced psychiatrist utilizing the Structured Clinical Interview for DSM-5 (SCID); * had an illness duration of at least 12 months; * were able to participate in the entire trial and face-to-face on-site assessment
Exclusion criteria
* pregnant or breastfeeding; * suffered from organic brain diseases or severe physical illness; * had a history of substance or alcohol abuse * were at high risk of suicide
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Obsessive-compulsive symptoms | Baseline, week 4, week 8 | Using the score of Yale-Brown Obsessive-Compulsive Scale as the primary outcome, a decrease in score of ≥35% was considered a 'response to treatment', also referred to as a 'full response', and a decrease in score of ≥25% was considered a 'partial response' |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Self-reported obsessive-compulsive symptoms | Baseline, week 4, week 8 | The reduction rate of the score of Obsessive-Compulsive Inventory-Revised (OCI-R), a self-rating scale of OCD symptoms severity, was employed as a secondary outcome |
| Cognitive inhibition | Baseline, week 8 | Cognitive inhibition was assessed using the emotional color-word Stroop task. The emotional Stroop task is a type of being Widely used cognitive inhibition assessment tools. The longer the reaction time, the worse the cognitive inhibition ability. |
| Behavioral inhibition | Baseline, week 8 | Behavioral inhibition was assessed using the emotional stop signal task (SST). The emotional SST task is a type of being Widely used behavioral inhibition assessment tools. Among them, the greater the SSRT, the worse the behavioral inhibition ability. |
| ERP components associated with cognitive function | Baseline, week 8 | To explore the ERP component analysis related to cognitive inhibition and Behavioral inhibition in obsessive-compulsive disorder (OCD) by event related potential (ERP) analysis |
| rest fMRI in Obsessive-compulsive patients | Baseline, week 8 | The changes of resting-state functional connectivity were analyzed in patients with OCD before and after intervention. Resting-state functional connectivity：FC(Functional connectivity). Resting-state functional brain imaging data were collected using a GE 3.0T magnetic resonance scanner (GE Discovery MR750) at the Brain Imaging Center, Institute of Psychology, Chinese Academy of Sciences. |
Countries
China
Contacts
Primary ContactXiang Y Zhang, M.D., Ph.D
Outcome results
None listed