Calcific Coronary Arteriosclerosis, Coronary Stenosis
Conditions
Keywords
Cardiac Computed Tomography, Photon Counting Detector
Brief summary
Coronary CT angiography is challenging in patients with more than mildly calcified coronary vessels, because of calcium artefacts that prevents evaluation of the lumen. The purpose of the CCT-PCD-1-study is to evaluate the diagnostic accuracy and image quality in coronary CT angiography using a commercially available CT system equipped with a photon counting detector technology. Patients referred for cardiac CT and conventional coronary angiography as part of routine preoperative evaluation before Transcatheter Aortic Valve Implantation (TAVI) will be asked for inclusion in the study. This group of patients has generally a coronary artery calcium burden and perform cardiac CT and coronary angiography as part of routine care. The diagnostic accuracy concerning significant coronary artery stenosis on the preoperative CT will be evaluated with the conventional coronary angiography as reference. Also, CT examination image quality will be evaluated.
Interventions
DIAGNOSTIC_TESTCardiac CT with photon counting detector
Cardiac CT including the coronary arteries. The cardiac CT is performed in routine care for the included patients.
Sponsors
Region Örebro County
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients referred for cardiac CT AND conventional coronary angiography as part of routine preoperative evaluation.
Exclusion criteria
* \<65 years old. * Heart arrhythmia. * Heart rate \>90/min with contraindication against beta blockers. * Not capable of giving informed consent * eGFR \<30 mL/min/1.73m2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic accuracy of CT concerning coronary stenosis with conventional angiography as reference | 1 day. (Coronary angiography is usually performed the same day as cardiac CT.) | Coronary angiography with or without FFR is performed as part of routine care for included patients. The outcome measure is the agreement between coronary CT and coronary angiography. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Image quality | 1 day. (Image quality is assessed on the performed examination) | Image quality on CT examination according to European guidelines on quality criteria for computed tomography |
Countries
Sweden
Outcome results
None listed