Non-melanoma Skin Cancer
Conditions
Brief summary
Vitamin D has a crucial role in cancer control and prevention.vitamin D receptor (VDR) and its heterodimer Retinoid X receptor (RXR) are equally important in the cell. This ligand (vitamin D) and receptors (VDR-RXR) complex together triggers downstream DNA damage response in the cell. Retinoid receptors are a superfamily of nuclear receptors. The preferred receptor that attaches to VDR is RXR, with its subunits α, β and γ. RXR α is more frequent in the skin than other tissues, while β occurs in internal organs and γ is frequently related to neural disorders. the investigator hopes to assess prognosis of SCC & BCC by using RXR-α biomarker & attempts to use it in the treatment.
Interventions
None listed
Sponsors
Sohag University
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
1. Squamous cell carcinoma and basal cell carcinoma. 2. Incisional & excisional biopsies. 3. All the studied cases include sufficient materials for the immunohistochemical study 4. Complete clinical data
Exclusion criteria
1. Patients with a history of preoperative chemotherapy and/or radiotherapy. 2. Insufficient or tiny tissue biopsies.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma | One or two days after staining sections with the marker. | immuohistochemical expression of RXR-α in Squamous and Basal Cell Carcinoma |
Contacts
Primary ContactFatma M.Hamdan
Outcome results
None listed