Out-Of-Hospital Cardiac Arrest, Advanced Cardiac Life Support, Ventilation
Conditions
Brief summary
Comparison of Manual Ventilation and Automatic Mechanical Ventilation during CPR, Pilot & Feasibility Study (CAVE-I trial)
Detailed description
This is a preliminary randomized clinical trials comparing the effectiveness of the automatic mechanical ventilation method compared to manual ventilation methods commonly performed during advanced cardiac life support (ACLS) in emergency room for out-of-hospital cardiac arrest.
Interventions
DEVICEAutomatic Mechanical Ventilation
Ventilation settings: Mode: (S)Continuous Mandatory Ventilation Rate: 10 b/min. Tidal Volume: 500 ml (male), 450 ml (female) I:E=1:1 Positive end expiratory pressure (PEEP): 5 cmH2O Flow trigger: off Oxygen: 100% Alarms: Pressure 70 cmH20, Tidal volume 100 \ 1,000 ml
DEVICEManual Ventilation
Ambu-bagging (It is recommended in the guidelines as a ventilation method.) Methods: 10 times per minutes by medical personnel
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
It is a study conducted by random assignment to two groups of manual ventilation and automatic mechanical ventilation.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Out-of-hospital cardiac arrest (OHCA) * Transferred by only EMS without prehospital return of spontaneous circulation (ROSC) * ACLS for at least 20 minutes in the emergency room * Arterial blood gas analysis at least once during ACLS
Exclusion criteria
* In-hospital cardiac arrest (IHCA) * Not transferred by Emergency Medical Service * ROSC gained before arriving at the ER * OHCA caused by trauma * ACLS is not performed for more than 20 minutes because the death is obvious * Not able to intubate the trachea
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ROSC: return of spontaneous circulation | Within 20 minutes of ACLS | Rate of any ROSC after ACLS |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Arterial blood gas analysis (ABGA) parameters | The first test was conducted within 5 minutes of ACLS, and the second test 10 minutes after the first test. | PH (no unit), PO2 in mmHg, PCO2 in mmHg, HCO3 in mEq/L |
| Ventilation parameters | During the entire ACLS time after randomization and endotracheal intubation | Tidal volume (TV) and Minute volume (MV) during the entire ACLS |
Other
| Measure | Time frame | Description |
|---|---|---|
| Peak pressure (only in automatic mechanical ventilation group) | Randomized by automatic mechanical ventilation and during the entire ACLS time after endotracheal intubation | Peak pressure of ventilator during the entire ACLS |
Countries
South Korea
Outcome results
None listed