IPSC Repository of Pediatric Cardiovascular Disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05550324

Enrollment

300

Registered

2022-09-22

Start date

2021-07-02

Completion date

2030-12-31

Last updated

2025-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Congenital Heart Disease, Heart Diseases

Keywords

iPSC

Brief summary

Obtain blood samples for generation and maintenance of induced pluripotent stem cells (iPSCs) and genomic/DNA sequencing for biomedical research that will improve the understanding and treatment of pediatric cardiovascular disease

Detailed description

Human induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cell which can be generated from easily accessible patient cells, such as peripheral blood mononuclear cells and skin fibroblasts. As iPSCs are epigenetically reprogrammed from somatic cells, they retain all genetic information of the affected patients, thus providing an ideal model for studying the contribution of genetic variation to pediatric cardiovascular disease. In addition, human iPSCs can be differentiated into cardiomyocytes, endothelial cells, smooth muscle cells and cardiac fibroblasts, which are major affected cell types in the heart responsible for cardiovascular disease. Therefore, patient-specific iPSCs possess great promise in modeling pediatric cardiovascular disease, discovering novel drugs and prospective cell regeneration therapy. The DNA from these patients will be analyzed for point mutations, rare sequence variations, single nucleotide polymorphisms in known cardiac development genes or for chromosomal copy number changes by using state of the art genetic approaches.

Interventions

PROCEDUREBlood draw

One time intravenous blood draw

Study design

Observational model

FAMILY_BASED

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

1. The subjects must have the diagnosis of cardiovascular disease 2. The subject must have a syndrome associated with cardiovascular disease 3. The subject must be related to an individual in cohort 1 or 2 4. The subject is considered a control and does not fall into any of the other cohorts

Exclusion criteria

N/A

Design outcomes

Primary

Measure	Time frame	Description
improve the understanding and treatment of pediatric cardiovascular disease	up to 10 Years	This is a repository of blood samples that will be used into the future for medical research to improve the understanding and treatment of pediatric cardiovascular disease

Countries

United States

Contacts

Primary ContactJade F Hayden, BSN

jade.hayden@nationwidechildrens.org16143555648

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026