Obstructive Sleep Apnea
Conditions
Keywords
Continues Positive Airway Pressure, High-flow Nasal Cannula Oxygen Therapy
Brief summary
Patients meeting the criteria of obstructive sleep apnea were included, and all patients signed informed consent, which met the requirements of the ethics Committee of our unit. All subjects were hospitalized patients. Subjects were randomly enrolled into High-flow Nasal Cannula Oxygen Therapy group or Continues Positive Airway Pressure group for 3 days of treatment. Sleep monitoring was performed on the first and fourth day of enrollment.
Interventions
DEVICEhigh-flow nasal cannula oxygen therapy,
Patients were treated with high-flow nasal cannula oxygen therapy for three nights
DEVICECPAP
Patients were treated with CPAP for three nights
Sponsors
Qilu Hospital of Shandong University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. There were typical symptoms of sleep snoring at night with apnea and daytime sleepiness (ESS score ≥9). Stenosis and obstruction in any part of the upper airway were observed on physical examination, with AHI≥5 times /h. 2. For patients with no significant daytime sleepiness (ESS score \< 9), AHI≥10 times /h. 3. Patients with AHI≥5 times /h had one or more OSAHS complications, such as cognitive impairment, hypertension, coronary heart disease, cerebrovascular disease, diabetes and insomnia.
Exclusion criteria
1. Patients who cannot tolerate non-invasive ventilator or transnasal high-flow oxygen therapy. 2. Ongoing treatment may affect sleep, such as sedatives, hypnotics, muscle relaxants, etc. 3. Hemodynamic instability. 4. Severe respiratory diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| minimum oxygen saturation | The first day of enrollment | Lowest oxygen saturation during the patient's night sleep |
| AHI | The first day of enrollment | Apnea Hypopnea Index:The number of episodes of sleep apnea per hour |
| Treatment failure rate | The fourth day of enrollment | Number of patients unable to tolerate treatment/enrollment |
| Good compliance rate | The fourth day of enrollment | Number of patients treated for more than 4 hours per night/enrolled |
| longest apnea time | The first day of enrollment | Maximum duration(s) of nocturnal sleep apnea in patients |
| Mean oxygen saturation | The first day of enrollment | Mean oxygen saturation during the patient's night sleep |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gender | The first day of enrollment | Male and female |
| height | The first day of enrollment | Height (in cm) |
| age | The first day of enrollment | years |
| weight | The first day of enrollment | Kg |
| total sleep time | The first day of enrollment | Total sleep duration(min) of the patient at night |
| Number of awakening | The first day of enrollment | The number of awakenings during the patient's night sleep |
Countries
China
Contacts
Primary ContactDedong Ma, doctor
Outcome results
None listed