Glaucoma
Conditions
Keywords
outflow facility, microshunt, ab interno trabeculectomy, pneumatonometer, intraocular pressure
Brief summary
The purpose of this study was to asses differences in nycthemeral (24-h) intraocular pressure (IOP) profiles and outflow facilities between patients who have undergone epibulbar microshunt implantation and ab interno trabeculectomy, respectively.
Detailed description
Recent studies involving continuous, 24-hour intraocular pressure (IOP) monitoring in glaucoma patients linked IOP variation to disease progression. No study has previously compared the postoperative IOP variation of microshunt (Preserflo, P) implantation to ab interno trabeculectomy (Trabectome, T). In this prospective cohort, the investigators analyzed 68 patients (34 P and 34 T) who presented for 24-hour IOP monitoring 6 to 12 months after surgery. Surgery must have been conducted between October 2020 and July 2021. Patients were assigned to each study group according to the intervention undergone, P or T. IOP and tonographic outflow facility were measured in the habitual position using a pneumatonometer. The IOP variation was considered the primary outcome measure.
Interventions
DIAGNOSTIC_TESTPneumatonometry after microshunt implantation
Pneumatonometry was perfomed over 24 hours at 5 point in time (5 AM, 11 AM, 4 PM, 8 PM, and midnight) using a Pneumatonometer. The measurement was conducted in the habitual position.
DIAGNOSTIC_TESTPneumatonometry after ab interno trabeculectomy
Pneumatonometry was perfomed over 24 hours at 5 point in time (5 AM, 11 AM, 4 PM, 8 PM, and midnight) using a Pneumatonometer. The measurement was conducted in the habitual position.
Sponsors
Wuerzburg University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients that have undergone microshunt implantation or ab interno trabeculectomy between 6-12 months ago * patients suffering from open-angle glaucoma
Exclusion criteria
* Patients that have undergone microshunt implantation or ab interno trabeculectomy less than 6 months or over 12 months ago * patients suffering from angle-closure glaucoma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intraocular pressure variation | Obtained 6-12 months after patients have undergone microshunt implantation and ab interno trabeculectomy, respectively. Measurements were taken at 5 points in time over 24 hours (at 5 AM, 11 AM, 4 PM, 8 PM, and midnight). | 24-hour variation in intraocular pressure obtained by the use of a pneumatonometer. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Outflow facility | Obtained 6-12 months after patients have undergone microshunt implantation and ab interno trabeculectomy, respectively. Measurements were taken at 5 points in time over 24 hours (at 5 AM, 11 AM, 4 PM, 8 PM, and midnight). | Outflow facility of the aqueous humor from the eye obtained by pneumatonography. |
| Intraocular pressure | Obtained 6-12 months after patients have undergone microshunt implantation and ab interno trabeculectomy, respectively. Measurements were taken at 5 points in time over 24 hours (at 5 AM, 11 AM, 4 PM, 8 PM, and midnight). | Intraocular pressure obtained by the use of a Pneumatonometer |
Countries
Germany
Outcome results
None listed