Corneal Endothelial Cell Injury Induced by Mitomycin-C

Corneal Endothelial Cell Injury Induced by Mitomycin-C in TransEpi Single Step and Alcohol Assisted Photorefractive Keratectomy PRK: A Comparative Study

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05548478

Enrollment

Registered

2022-09-21

Start date

2022-09-30

Completion date

2023-02-28

Last updated

2022-09-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myopia

Keywords

mytomycin

Brief summary

our study will investigate the effecacy of Mitomycin-C in TransEpi single step photorefractive keratectomy (PRK) and alcohol assisted PRK

Interventions

PROCEDURETransepithelial PRK/MMC

transepithelial photorefractive keratectomy (PRK) and mitomycin C addition

PROCEDUREAlcohol-Assisted PRK/MMC

photorefractive keratectomy (PRK) assisted by alchol and mitomycin C addition

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

17 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Age over 18 years. * Primary myopia or compound myopic astigmatism. * Preoperative manifest refraction spherical equivalent (MRSE) within the range of -1.0 to 8 D * Stable refractive error for at least 12 months before the surgery. * Contact lens discontinuation for at least 3 weeks. * Estimated corneal stromal bed thickness of more than 300mm at the thinnest point

Exclusion criteria

* Unwilling to participate in the study. * Previous ocular surgery * Any diagnosed ocular disease * History of ocular trauma

Design outcomes

Primary

Measure	Time frame	Description
Endothelial cell Density	Base line	will be measured by Specular microscopy

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026