Postoperative Delirium
Conditions
Brief summary
To explore the correlation between tear metabolomics and POD. The purpose of this study was to compare the results of tear metabolomics between POD and non-POD elderly patients undergoing abdominal surgery, to clarify the correlation between tear metabolomics and POD, and to find tear markers related to POD.
Interventions
None listed
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* age 65-90 years old; * ASA I-III; * patients who plan to undergo elective abdominal surgery under general anesthesia; * Volunteer to participate in this study and sign informed consent.
Exclusion criteria
* patients with known mental illness or lack of communication or cognitive impairment before operation; * severe vision, hearing, language impairment or other reasons unable to communicate with visitors; * severe dysfunction of important organs such as heart, brain, lung, liver, kidney, etc.; * long-term use of sedatives, antidepressants or alcoholism; * patients with severe postoperative complications and admitted to intensive care unit; * patients who refused or failed to complete the cognitive function test. * patients who could not cooperate with the study for any other reason
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative delirium during the 3 adys-follow-up after anesthetic resuscitation | From ending of the surgery to 3 days after anesthetic resuscitation | Postoperative delirium was tested with 3D-Confusion Assessment Method or Confusion Assessment Method-intensive care unit (0-4, higher scores means worse). The patient is determined to be postoperative delirium (ie, Confusion Assessment Method positive) if he/she fall ill quickly with confusion disorder, and with mental disorder or consciousness disorder. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative delirium in the postanesthesia care unit | From ending of the surgery to the time when discharge from postanesthesia care unit, an average of 30 minutes. | Postoperative delirium was tested with Confusion Assessment Method-intensive care unit. Postoperative delirium was tested with Confusion Assessment Method-intensive care unit (0-4, higher scores means worse outcome). The patient is determined to be postoperative delirium (ie, Confusion Assessment Method positive) if he/she fall ill quickly with confusion disorder, and with mental disorder or consciousness disorder. |
| Postoperative delirium on the first day after operation | 9：00-10：00 and 15：00-16：00 on The first day after operation | Postoperative delirium was tested with 3D-Confusion Assessment Method (0-4, higher scores means worse outcome). The patient is determined to be postoperative delirium (ie, Confusion Assessment Method positive) if he/she fall ill quickly with confusion disorder, and with mental disorder or consciousness disorder. |
| Postoperative delirium on the second day after operation | 9：00-10：00 and 15：00-16：00 on The second day after operation | Postoperative delirium was tested with 3D-Confusion Assessment Method (0-4, higher scores means worse outcome). The patient is determined to be postoperative delirium (ie, Confusion Assessment Method positive) if he/she fall ill quickly with confusion disorder, and with mental disorder or consciousness disorder. |
| Postoperative delirium on the third day after operation | 9：00-10：00 and 15：00-16：00 on The third day after operation | Postoperative delirium was tested with 3D-Confusion Assessment Method (0-4, higher scores means worse outcome). The patient is determined to be postoperative delirium (ie, Confusion Assessment Method positive) if he/she fall ill quickly with confusion disorder, and with mental disorder or consciousness disorder. |
Countries
China
Outcome results
None listed