Compare Unimodal and Multimodal Analgesics
Conditions
Brief summary
Many surgical procedures are accompanied by postoperative pain with severity moderate, severe or extreme and insufficient postoperative pain control may cause risk of post-surgical complications and risk of chronic post-surgical pain The targets of preoperative pain management are to relieve patient suffering, reduce length of hospital stay and achieve early mobilization after surgery, decreasing opioid consumption and its side effects that are constipation, nausea, vomiting, dizziness, respiratory depression which is the most feared complication being life-threatening and some less common side effects as sedation
Interventions
DRUGPregabalin 150mg
Pregabalin 150mg preoperative in unimodal group Pregabalin 150mg preoperative in multi-modal group
DRUGAcetaminophen 1 G Oral Tablet
Acetaminophen 1 G Oral Tablet preoperative in multi-modal group
DRUGCelecoxib 400Mg Oral Capsule
Celecoxib 400Mg Oral Capsule preoperative in multi-modal group
Sponsors
Beni-Suef University
October 6 University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing laparoscopic cholecystectomy * Patients older than 18 years old
Exclusion criteria
* Renal or hepatic or cardiac impairment patients * Patients with chronic pain history * Allergic patients after taking aspirin or other NSAIDs * patients with active gastrointestinal bleeding, ulcer and inflammatory bowel diseases or cerebrovascular bleeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative visual analogue scale (VAS) | 24 hour postoperative | The visual analog scale (VAS) is a simple and often used method for evaluating variations in pain intensity. |
| Amount of post operative Needed opioid analgesia | 24 hour postoperative | ampules of opioid analgesia needed after operation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Type and amount of prescribed post operative non opioid analgesia | 24 hour postoperative | Type and amount of prescribed post operative non opioid analgesia |
Other
| Measure | Time frame | Description |
|---|---|---|
| Reported opioid side effects | 24 hour postoperative | Side effects reported after opioid administration eg. nausea, vomiting, respiratory depression etc.. |
Countries
Egypt
Outcome results
None listed