Aneuploidy, Chromosome Abnormality, Infertility
Conditions
Keywords
IVF, PGT-A, NON- INVASIVE PGT-A, TIME LAPSE, EMBRYO SELECTION
Brief summary
This is a prospective randomised study of the evaluation of the clinical IVF results after invasive PGT-A embryo selection versus Non-invasive PGT-A assisted embryo selection in subfertile women.
Detailed description
A randomized prospective study focusing on subfertile women undergoing IVF treatment followed by embryo transfer on the blastocyst stage. Women assigned to group A proceed to embryo transfer, after invasive PGT-A embryo selection, while women of group B after non-invasive PGT-A assisted embryo selection. IVF outcomes, regarding the success rate of the trasnfer and the time required to achieve conception is studied in both groups.
Interventions
DIAGNOSTIC_TESTembryo selection
The basis of embryo selection for transfer: invasive PGT-A or after non-invasive PGT-A
Sponsors
Assisting Nature
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
40 Years to 54 Years
Healthy volunteers
Yes
Inclusion criteria
* Women who followed IVF treatment * 40 years old or older * Single embryo transfer * blastocyst stage cultured embryos
Exclusion criteria
* women under the age of 40 years * not blastocyst transfer (transfers performed at earlier embryo stage) * double embryotransfer * women who had embryotransfer according to morphological criteria women whose embryos were not time-lapse monitored
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Embryotransfers to conceive | Up to the embryotransfer of the last enrolled patient (Dec 2023) | The number of the embryotransfers required for women to conceive |
| Time interval to conceive | Up to the pregnancy test after the last embryo transfer of an enrolled patient (Jan 2024) | Time interval required for women to conceive (in months): from day of first embryotransfer to positive hCG test |
| Cumulative Live Birth Rate | Up to 38 weeks after the embryo transfer | Cumulative Live Birth Rate achieved after one OPU treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Abortion rate | Up to 2nd trimester miscarriages | The spontaneous miscarriage of women in both groups |
| DaC rate | during pregnancy according to Greek Law | The rate of the dilation and curretage rate in both groups |
Countries
Greece
Contacts
Primary ContactEvangelos Papanikolaou, MD, PhD
Backup ContactMaria Galiotou, MSc
Outcome results
None listed