Non-Alcoholic Fatty Liver Disease
Conditions
Keywords
Non-Alcoholic Fatty Liver Disease, Cohort Studies, Risk Factors
Brief summary
Metabolic associated fatty liver disease(MEFLD) is a major chronic liver disease that can lead to various adverse events, such as liver cancer, cardiovascular disease, and chronic kidney disease. The present community-based cohort study enrolls subjects who take health physical examinations at the sub-center outpatient department, Beijing Friendship Hospital. Investigators collect their baseline information, including demographic data, clinical history, physical examination, laboratory results, imageological examination, and so on. Follow-up surveys are conducted annually and the information collected is the same as the baseline. The outcome information, including cardiovascular disease, malignancy, liver cirrhosis, liver decompensation, liver transplantation, and all-cause mortality, are obtained by linking to the hospital discharge database and death registration system of Beijing. The primary aim of the study is to build a risk-stratified evaluation system for MAFLD through the cohort.
Detailed description
The present community-based cohort study enrolls subjects who take physical health examinations at the sub-center outpatient department, Beijing Friendship Hospital. After signing the informed consent, Their previous health physical examination results, which were recorded in the Hospital Information System (HIS) are collected retrospectively. Then, Investigators collect their baseline information, including demographic data, clinical history, physical examination, laboratory results, image logical examination, and so on. Additionally, follow-up surveys will be conducted annually and the information collected is the same as the baseline. The outcome information, including cardiovascular disease, malignancy, liver cirrhosis, liver decompensation, liver transplantation, and all-cause mortality, is obtained from the hospital discharge database and death registration system in Beijing. The study's primary aim is to build a risk-stratified evaluation system for MAFLD through a community population cohort with long-term stable follow-up.
Interventions
None listed
Sponsors
Chinese Academy of Medical Sciences
Beijing Friendship Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Aged 18 years or older * Permanent residents in Beijing * Signing informed consent
Exclusion criteria
* No
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiovascular disease | 1 to 10 years | Incidence of cardiovascular disease during follow-ups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Malignancy | 1 to 10 years | Incidence of malignancy during follow-ups |
| Liver cirrhosis | 1 to 10 years | Incidence of liver cirrhosis during follow-ups |
| Liver decompensation | 1 to 10 years | Incidence of liver decompensation during follow-ups |
| Liver transplantation | 1 to 10 years | Incidence of liver transplantation during follow-ups |
| All-cause mortality | 1 to 10 years | Incidence of all-cause mortality during follow-ups |
Countries
China
Contacts
Primary ContactHong You, Doctor
Backup ContactXinyu Zhao, Doctor
Outcome results
None listed