Aneuploidy, Chromosome Abnormality, Infertility
Conditions
Keywords
IVF, PGT-A, NON- INVASIVE PGT-A, TIME LAPSE, EMBRYO SELECTION
Brief summary
This is a prospective randomised study of the evaluation of the clinical IVF results after time lapse assisted embryo selection versus Non-invasive PGT-A assisted embryo selection in subfertile women.
Detailed description
A randomized prospective study focusing on subfertile women undergoing IVF treatment followed by embryo transfer on the blastocyst stage. Women assigned to group A proceed to embryo transfer, after time lapse assisted embryo selection, while women of group B after non-invasive PGT-A assisted embryo selection. IVF outcomes, regarding the success rate of the trasnfer and the time required to achieve conception is studied in both groups.
Interventions
OTHERembryo selection
The basis of embryo seletion for transfer: morphological or genetic after non-invasive PGT-A
Sponsors
Assisting Nature
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* Women who followed IVF treatment * 39 years old or younger * Single embryo transfer * blastocyst stage cultured embryos
Exclusion criteria
* women over the age of 39 years * not blastocyst transfer (transfers performed at earlier embryo stage) * double embryotransfer * women who had invasive PGT-a test * women whose embryos were not time-lapse monitored
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Embryotransfers to conceive | Up to the embryotransfer of the last enrolled patient (Dec 2023) | The number of the embryotransfers required for women to conceive |
| Time interval to conceive | Up to the pregnancy test after the last embryo transfer of an enrolled patient (Jan 2024) | Time interval required for women to conceive (in months): from OPU day to positive hCG test |
| Cumulative Live Birth Rate | Up to 38 weeks after the embryo transfer | Cumulative Live Birth Rate achieved after one OPU treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Abortion rate | Up to 2nd trimester miscarriages | The spontaneous miscarriage of women in both groups |
| DaC rate | Up to 24 weeks of pregnancy according to Greek Law | The rate of the dilation and curretage rate in both groups |
Countries
Greece
Contacts
Primary ContactEvangelos Papanikolaou, MD,PhD
Backup ContactMaria Galiotou, MSc
Outcome results
None listed