Healthy Volunteers
Conditions
Keywords
thoracic aorta, MRI, acquisition calibration, biomarkers
Brief summary
The main objective is to optimize MRI acquisition and image post-processing protocols in order to define the best compromise between short scan time and image quality (contrast between different tissues, spatial and temporal resolutions) high enough to accurately measure morphologic, hemodynamic and structural aortic biomarkers.
Detailed description
This Magnetic Resonance imaging study of the thoracic aorta aims to: 1- enhance patient comfort during the examination, shorten appointment waiting times and overall reduce MRI cost, and 2- provide a reliable diagnosis and risk assessment of aorta-related diseases occurring in hypertension, obesity or diabetes but also throughout normal aging. The impact of MRI acquisition innovations on the measurement of biomarkers that are extracted from image post-processing software and therein on disease characterization (normal values, severity thresholds, etc.) must be systematically reevaluated. More specifically, the investigators design image acquisition and automated image processing methods to reduce operator variability. This study will optimize thoracic aortic MRI acquisition sequences for the quantification of diagnostic-assisting biomarkers in a healthy population.
Interventions
OTHERMRI calibration
Non-injected thoracic aorta MRI calibration
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Subject aged between 20 and 35 or between 50 and 70 (limits included) * BMI \< 30 kg/m² * Asymptomatic subject * Having given informed, free and written consent * Affiliated to a French social security scheme or entitled
Exclusion criteria
* Contraindication to MRI (claustrophobia, presence of a metallic foreign body) * Pregnant or breastfeeding woman * Known cardiac pathology * Personal cardiovascular history * Person deprived of liberty by court decision or benefiting from legal protection (under guardianship or curatorship) * Abuse of alcohol or narcotics * Subject under AME * Participation in another interventional research involving the human person or being in the exclusion period at the end of a previous research involving the human person
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Parametric measurement of thoracic aorta values of normal subjects | 24 months | Thoracic aorta values measured by MRI |
Secondary
| Measure | Time frame |
|---|---|
| Quantitative fat within the aortic wall (%) | 24 months |
| Quantitative periaortic fat (g and g/m², when indexed to BSA) | 24 months |
| ROC metrics will be used to compare the various sequences (%) | 24 months |
| Quantitative fibrosis within the aortic wall (%) | 24 months |
| Correlation coefficients will be estimated to assess the associations between novel and conventional biomarkers | 24 months |
| Intra and inter-reproductibility of aortic measures will be assessed (intra-class correlation coefficients) | 24 months |
| Intra and inter-reproductibility of aortic measures will be assessed (Bland and Altman metrics) | 24 months |
| Quantitative flow values within the different aortic segments and the main branches (mL) | 24 months |
Countries
France
Contacts
Primary ContactRaluca PAIS, MD
Backup ContactNadjia KACHENOURA, PhD
Outcome results
None listed