Phantom Pain
Conditions
Keywords
fMRI, spinal fMRI
Brief summary
The amputation of a limb results in chronic pain associated with the lost limb in the majority of patients, which persists over time. Despite a large number of studies conducted in an attempt to elucidate the neural basis of phantom pain, these are still not elucidated and current treatments often fail to relieve patients' pain.
Interventions
OTHERQuestionnaires
Short-Form McGill Pain Questionnaire (SF-MPQ) Pain Disability Index (PDI) Prosthesis Evaluation Questionnaire (PEQ) Psychological Inflexibility to Pain Scale (PIPS) Chronic Pain Acceptance Questionnaire (CPAQ) Cognitive Difficulties Scale (CDS) Amputee Body Image Scale (ABIS) Trinity Amputation and Prosthesis Experience Scales (TAPES) Pain Catastrophizing Scale (PCS) Hospital Anxiety and Depression Scale (HAD) Credibility/Expectancy Questionnaire (CEQ) Short-Form Edinburgh Handedness Inventory (SF-EHI) Patient's Global Impression of Change (PGIC)
DEVICEBrain and Spinal Cord functional Magnetic Resonance Imaging
Brain and Spinal Cord functional Magnetic Resonance Imaging
Proprioceptive muscular training via a mechanical vibration of low amplitude and frequency between 60 and 80 Hz applied to the tendons.
Sponsors
Direction Centrale du Service de Santé des Armées
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Inclusion criteria
* Between 18 and 65 years old * For the amputees with phantom pain group: patients who have been amputated for more than 2 years and have chronic phantom pain * For the amputees without phantom pain group: patients who have been amputated for more than 2 years and do not have chronic phantom pain * For the healthy participants group: healthy participants with no neurological history
Exclusion criteria
* Clinically significant pathology (gastrointestinal, renal, hepatic, endocrine, cardiovascular or respiratory) * Progressive psychiatric or neurological pathology * On psychotropic medication * Pregnant or nursing woman * Inadequate level of French language
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in brain activity, measured through fMRI, following proprioceptive training | Up to 3 months | Brain activity (BOLD hemodynamic response) will be measured via fMRI before and after proprioceptive training sessions. |
| Change in spinal cord activity, measured through spinal fMRI, following proprioceptive training | Up to 3 months | Spinal cord activity (BOLD hemodynamic response) will be measured via spinal fMRI before and after proprioceptive training sessions. |
Outcome results
None listed