Rheumatoid Arthritis
Conditions
Brief summary
Trivalent chromium has shown good results in abolishing inflammation and had a successful result in treating animal model of rheumatoid arthritis. In addition to that, trivalent chromium lacks many side effects which are related to the already known medications of the disease. So this study aims to evaluate the efficacy of trivalent chromium supplementation in rheumatoid arthritis treatment and measuring the outcomes of that in rheumatoid arthritis patients.
Detailed description
Rheumatoid arthritis is a debilitating autoimmune disease which is treated by medications that have many side effects. Trivalent chromium, a naturally occurring element with regulatory effects on blood sugar, has shown anti-inflammatory properties in many studies and has shown a good response at alleviation of rheumatoid arthritis in the disease animal model. For these reasons trivalent chromium should be tried in rheumatoid arthritis patients.
Interventions
DRUGTrivalent chromium versus synthetic and/ or biological DMARDs
Supplement and immunesuppressants
Sponsors
Alexandria University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* rheumatoid arthritis
Exclusion criteria
* other autoimmune diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Radiological investigations if required (X-RAY, ultrasound, MRI, bone scan) | three months | To assess joints and bone |
| Arthritis scored by DAS28 score | three months | DAS 28 is a score of arthritis |
| ESR in mm/hr | three months | lab measures for disease activity |
| CRP mg/dL | three months | lab measures for disease activity |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum urea | three months | A renal function test to exclude trivalent chromium side effects. |
| serum creatinine | three months | A renal function test to exclude trivalent chromium side effects. |
| SGOT | three months | A liver function test to exclude trivalent chromium side effects. |
| SGPT | three months | A liver function test to exclude trivalent chromium side effects. |
Countries
Egypt
Outcome results
None listed