Athlete Heart
Conditions
Keywords
speckle tracking echocardiography, myocardial deformation, functional capacity, layer-specific strain
Brief summary
Echocardiographic assessment of the endurance athletes' heart remains challenging due to a phenotypic overlap between reactive physiological adaptation and pathological remodelling. The lower range of normal values of lLeft ventricle systolic ejection fraction (LVEF) and global longitudinal strain (GLS) in athletes makes it difficult to differentiate changes related to adaptive remodelling or indicative of early cardiomyopathy. This study aims to improve the assessment of athletes' hearts by identifying echocardiographic phenotypes, using a speckle tracking including temporal deformation pattern and layer-specific approach, and to define predictive factors of subtle LV systolic dysfunction and of mechanical LV abnormalities.
Detailed description
Healthy male athletes belonging to local clubs, who underwent a pre-participation medical evaluation at the University Hospital of Nancy between 2013 and 2020, will be screened. Clinical, echocardiographic and cardiopulmonary exercise testing data will be compared to a group of healthy men from the STANISLAS cohort. Subtle LV dysfunction will be defined by a GLS \<17.5%.
Interventions
OTHEREchocardiography
Transthoracic echocardiography
OTHERCardiopulmonary exercise testing
Cardiopulmonary exercise testing
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
INSERM, CIC 1433
Central Hospital, Nancy, France
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
\- athletes who underwent a pre-participation medical evaluation in the Nancy University Hospital between January 1st, 2013, and January 1st, 2020
Exclusion criteria
* female athletes, * athletes followed for cardiomyopathy * athletes who did not have transthoracic echocardiography (TTE) performed.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Multilayer (= epi- and endocardial) left ventricular global longitudinal strain using Speckle-tracking echocardiography | Baseline | expressed in % |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| left ventricular End-diastolic volume | baseline | ml |
| Cardiac Index | baseline | ml/min/m² |
| Maximal E-wave velocity and Maximal A-wave velocity | baseline | m/s |
| Left atrium End-systolic volume | baseline | ml/m² |
| left ventricular global longitudinal strain (peak G) assessed by Speckle-tracking echocardiography | baseline | expressed in % |
| PSI (pre stretch index) assessed by Speckle-tracking echocardiography | baseline | expressed in % |
| PST (postsystolic thickening) assessed by Speckle-tracking echocardiography | baseline | expressed in % |
| Peak VO2 | baseline | L/min |
| Left ventricular Ejection Fraction | baseline | using simpson's biplane method, expressed in % |
| Left ventricle indexed mass | baseline | g/m² |
| Age | Baseline | years |
| Height | baseline | meter |
| Weight | baseline | meter |
| BMI | baseline | kg/m² |
| Heart rate | baseline | bpm |
| Type of practiced sport | baseline | soccer, basketball, handball |
| Inter ventricular septum diameter | baseline | mm |
Countries
France
Outcome results
None listed