Application of Hyaluronic Acid in Diabetes

Evaluation of The Clinical & Radiographic Parameters in Controlled Type 2 Diabetic Patients Treated With Non-Surgical Periodontal Therapy With & Without Using Hyaluronic Acid Gel

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05543434

Enrollment

Registered

2022-09-16

Start date

2022-12-01

Completion date

2023-12-01

Last updated

2022-09-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Diseases

Brief summary

sub gingival application of hyaluronic acid create great clinical improvement of periodontal pocket treatment.

Detailed description

To clinically and radiographically evaluate the adjunctive effect of the local application of a 0.8% hyaluronan gel in addition to scaling and root planing in treatment of controlled diabetic patients with stage II periodontitis.

Interventions

DRUGHyaluronic acid

anti-inflammatory, anti-edematous, osseoinductive.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Age ≥ 18 years. * Patient with controlled diabetic type 2 (HgA1C \<7) (Mori et al., 2021). * Periodontitis stage II. * Periodontitis grade B. * Pocket depth \> 4 mm. * Smoking ≤ 10 cigarettes/day. * Cooperative patients able and accept to come for follow up appointments

Exclusion criteria

* • The use of antibiotics or anti-inflammatory drugs 1 month prior to the procedure and till the end of 6 months of follow-up. * Having surgical therapy or undergoing orthodontic treatment. * Ongoing drug therapy that might have an impact on the clinical signs and symptoms of periodontitis. * Pregnant and lactation females. * Smoking ˃ 10 cigarettes/day. * Patients with poor oral hygiene. * Any known allergies

Design outcomes

Primary

Measure	Time frame	Description
Clinical attachment level gain	3 months	Clinical attachment gain by using UNC15 Periodontal probe/ numerical data

Secondary

Measure	Time frame	Description
Pocket depth reduction	3 moths	Pocket depth reduction by using UNC15 Periodontal probe/ numerical data
Bleeding on probing	3 months	Bleeding on probing by using UNC15 Periodontal probe/ binary data
Gingival Recession	3 months	Gingival Recession by using UNC15 Periodontal probe/ numerical data
Radiographic Evaluation	3 months	by using periapical radiograph with standardized acrylic stent

Countries

Egypt

Contacts

Primary ContactReem M Alabbadi, BDS

reem.alabbadi@dentistry.cu.edu.eg00201551563633

Backup ContactNesma M Shemais, PHD

nesma.shemais@dentistry.cu.edu.eg00201005615697

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026