Potential Mechanisms Underlying the Microbiota-Gut-Kidney Axis in CKD
Conditions
Brief summary
Chronic kidney disease (CKD) is a progressive disease with hidden epidemics and one of the most significant contributing factors to end-stage renal disease (ESRD), cardiovascular comorbidities, cachexia and anemia, which accounts for a nearly 1.2 million populations died per year.
Interventions
BEHAVIORALrenal function
levels of eGFR
Sponsors
Shanghai 10th People's Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Age-matched and gender-matched HC with normal renal and liver function and not taking any medications were enrolled
Exclusion criteria
1. Age\<18 years. 2. Individuals with hypertension, diabetes, obesity, metabolic syndrome or pregnancy. 3. Individuals who received gastrointestinal operation, antibiotics or probiotic products within one month.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Functional and structural alteration of microbiotas and their crosstalk with CKD-associated metabolism | baseline | Gut metagenome, fecal metabolome and serum metabolome were performed in this disease-severity classified CKD cohort, to identify the changes of microbial compositions and metabolism in CKD progression |
Countries
China
Contacts
Primary ContactHaichao Wang
Outcome results
None listed