Healthy Cognition
Conditions
Brief summary
T-mult is an experimental study using low-frequency (1Hz) single-sesson rTMS to the DLPFC (versus sham rTMS) to explore the effect of virtual lesions on the brain network and cognition in 100 healthy adults (20-65 years old).
Interventions
DEVICErepetitive transcranial magnetic stimulation (rTMS)
real versus sham rTMS
Sponsors
Amsterdam UMC, location VUmc
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between 20 and 65 years old * Native Dutch speaker * Able to provide written informed consent
Exclusion criteria
* History of diagnosed neurological or psychiatric disease (including traumatic head injury) * Current and regular use of centrally acting drugs (recreational or prescribed, including analgesics), including the use of alcohol \ 8 hours prior to an appointment * Presence of any contraindications for MRI, MEG, or TMS (including resting motor threshold \>75% of maximum stimulator output or no useful motor-evoked potential elicitable) * Previous rTMS treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive change | baseline versus directly post-intervention (max. 8 weeks after baseline) | Change in performance on a neuropsychological test measuring cognitive functioning in the domain of executive functioning |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Brain network change | baseline versus directly post-intervention (max. 8 weeks after baseline) | Change in brain network organization as characterised by multimodal neuroimaging |
Countries
Netherlands
Outcome results
None listed