Determination of Pharmacokinetics of Different Curcuminoids Preparations: Pilot Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05542394

Enrollment

Registered

2022-09-15

Start date

2022-09-20

Completion date

2023-04-30

Last updated

2023-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Plasma Levels of Different Curcuminoids Preparations

Keywords

Curcumin H2O, Tumeric, piperine

Brief summary

This pilot study aims to investigate the pharmacokinetics of a novel curcuminoid preparation with suggested high bioavailability due to its solubility in water, compared to two standard hydrophobic formulations. The findings of this study will help the health care providers and community to select suitable formulation.

Detailed description

This pilot study is the first phase that must be followed, in the second phase, by longer clinical trials to support the findings and investigate the role of the novel preparation on health.The second phase will include an assessment of the effectiveness of several doses of curcumin preparation on health as well as an evaluation of the tolerance and possible adverse effects. The latter could not be evaluated at this stage of a single dose.

Interventions

DIETARY_SUPPLEMENTCurcumin

water soluble version of turmeric extract standardized to 10% curcuminoids .

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 25 Years

Healthy volunteers

Yes

Inclusion criteria

Male and female Apparently healthy adults

Exclusion criteria

Postmenopausal women Smokers Overweight Chronic diseases

Design outcomes

Primary

Measure	Time frame	Description
Blood concentration of bisdemethoxycurcumin	[Time Frame: Change during 8 hours]	plasma bisdemethoxycurcumin levels using LC MS/MS
Blood concentration of desmethoxycurcumin	[Time Frame: Change during 8 hours]	plasma desmethoxycurcumin levels using LC MS/MS
Blood concentration of piperine-curcuminoids	[Time Frame: Change during 8 hours]	plasma piperine-curcuminoids levels using LC MS/MS
Blood concentration of hexahydrocurcumin	[Time Frame: Change during 8 hours]	plasma hexahydrocurcumin levels using LC MS/MS
Blood concentration of curcumin diethyl disuccinate	[Time Frame: Change during 8 hours]	plasma curcumin diethyl disuccinate levels using LC MS/MS
Blood concentration of tetrahydrocurcumin	[Time Frame: Change during 8 hours]	plasma tetrahydrocurcumin levels using LC MS/MS
Blood concentration of curcumin	[Time Frame: Change during 8 hours]	plasma curcumin levels using LC MS/MS

Countries

Jordan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026