Effect of Acute Exercise on Exosome Associated Biomarkers

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05541133

Enrollment

Registered

2022-09-15

Start date

2022-06-21

Completion date

2024-12-31

Last updated

2025-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

This research study is being done to understand the underlying mechanism by which exercise affects the body on the cellular level, in an acute aerobic endurance setting. This may help to better understand the overall benefits of endurance exercise.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Ages: 18 to 45 years

Exclusion criteria

* BMI \>32 kg/m2. Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease. * Orthopedic problems that would keep them from being able to perform an exercise. - -- * Medications that are known to affect mitochondrial function: Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta-blockers, sulfonylureas, insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist). * Smoking. * Pregnancy.

Design outcomes

Primary

Measure	Time frame	Description
List of biomarkers	Baseline	Exosome proteomes and MiRNA from blood samples

Countries

United States

Outcome results