Tissue Eosinophils in Non-Small Cell Lung Cancer (the TEN Study)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05537701

Acronym

TEN

Enrollment

316

Registered

2022-09-13

Start date

2022-10-03

Completion date

2027-03-31

Last updated

2024-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-small Cell Lung Cancer

Brief summary

The primary objective is to describe eosinophil infiltration in resected (early stage) NSCLC. Secondary objectives are: * to investigate the correlation of T-Eos and B-Eos in the aforementioned patient population; * to investigate the correlation between T-Eos and overall & disease-free survival; * to investigate the localization of T-Eos (periphery vs. center of the tumor lesions).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Resected, early stage NSCLC between 01-01-2015 and 30-04-2022 with available tumour tissue

Exclusion criteria

* Inclusion in a clinical study contraindicating enrollment in the present study

Design outcomes

Primary

Measure	Time frame
Percentage of tumor associated tissue eosinophilia by immunohistochemistry and computerised quantification	October 2022

Secondary

Measure	Time frame	Description
to investigate the correlation of tissue (T)-Eos and blood (B)-Eos in the aforementioned patient population	December 2022	Tissue and blood eosinophil correlation
to investigate the correlation between T-Eos and overall & disease-free survival	December 2022	overall and disease-free survival
to investigate the localization of T-Eos (periphery vs. center of the tumor lesions)	December 2022	tissue eosinophil localisation

Countries

Belgium

Outcome results