Postprandial Glycemic Responses
Conditions
Keywords
enzymatic starch modification, postprandial glycemic responses
Brief summary
The aim of this study is to investigate whether enzymatic modification of starch in a food product using amylomaltase induces a lower glycemic response in healthy subjects compared to its unmodified counterpart.
Detailed description
A single-blind, randomized, cross-over study design will be applied. During each of the two study visits, healthy participants will consume an oatmeal porridge. One porridge will be treated will amylomaltase to modify the molecular structure of starch while the other porridge will serve as a control (unmodified counterpart). Blood glucose measurements will be taken postprandially at regular time points.
Interventions
DIETARY_SUPPLEMENTOatmeal porridge
Investigation of the impact of enzymatic modification of the molecular structure of starch by amylomaltase on the postprandial glycemic responses of an oatmeal porridge.
Sponsors
KU Leuven
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Body mass index (BMI) range 18.5 - 25.0 kg/m2 at screening visit * Fasting whole blood glucose values \< 6.3 mmol/L * Regular diet with 3 meals a day (at least 5 times a week) * Absence of health conditions that would prevent fulfillment of study requirements as judged by the Investigators on the basis of medical history * Willingness to maintain habitual diet, physical activity pattern, and body weight throughout the trial and refrain from smoking for 12 h prior to each visit * Willingness to abstain from alcohol consumption and to avoid vigorous physical activity for 24 h prior to study visits. * Adequate level of understanding spoken and written English * Willingness to provide informed consent to participate in the study
Exclusion criteria
* Failure to meet any one of the inclusion criteria * Recent participation in any clinical trial (\< 90 days) * Pregnant or lactating in the period of the study * Known history of AIDS, hepatitis, diabetes mellitus (Type I and II), cardiovascular disease, any pathology (or recent surgical event) of the gastrointestinal system or any current metabolic or endocrine disease * Alcohol consumption of \> 14 standard drinks for women and \> 21 standard drinks for men per week * Celiac disease or gluten intolerance * Use of medications known to influence carbohydrate metabolism, including, but not limited to adrenergic blockers, diuretics, thiazolidinediones, metformin and systemic corticosteroids the last 4 weeks before the screening visit * Use of antibiotics during the last three months * Reported slimming or medically prescribed diet * Unwillingness or inability to comply with the experimental procedures and to follow the safety guidelines
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose response | up to 3 hours | incremental area under the curve of blood glucose after oat porridge consumption |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Glucose response | up to 3 hours | peak rise of the blood glucose after oat porridge consumption |
Countries
Belgium
Outcome results
None listed