Retinal Vein Occlusion
Conditions
Keywords
Tumor necrosis factor alpha
Brief summary
To assess the levels of TNF- α in vitreous samples of patients with retinal vein occlusion prior to administration of intravitreal anti-VEGF and compare them to levels in vitreous samples of normal subjects so as to investigate the association of vitreous tumor necrosis factor with the pathogenesis of retinal vein occlusion.
Interventions
DIAGNOSTIC_TESTmeasurement of vitreous level of tumor necrosis factor alpha
measurement of vitreous level of tumor necrosis factor alpha using ELISA technique
Sponsors
Kasr El Aini Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Any patient with retinal vein occlusion not older than 6 months with no history of Anti-VEGF injection
Exclusion criteria
1. Diabetic patients. 2. Other causes of retinal vascular diseases. 3. Patients with history of treatment of retinal vein occlusion. 4. Previous intraocular surgery except cataract surgery performed 6 months before the study. 5. Subjects with severe systemic inflammatory diseases 6. Retinal vein occlusion secondary to retinal vasculitis. 7. All retinal pathologies. 8. Patients receiving Systemic steroids or Immunosuppressive therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| to assess vitreous level of tumor necrosis factor alpha in retinal vein occlusion and compare it to patient undergoing cataract surgery | Day 1 |
Countries
Egypt
Outcome results
None listed