Liver Neoplasms, Postoperative Analgesia, Serratus Anterior Plane Block
Conditions
Keywords
serratus anterior plane block, Postoperative analgesia, liver cancer
Brief summary
To investigate the clinical application of ultrasound-guided continuous low serratus anterior plane block in open surgery for hepatocellular carcinoma.
Detailed description
METHODS: Patients with hepatocellular carcinoma who attended our hospital from January 2021 to April 2023 were divided into CS group and N group according to the random number table method; CS group underwent ultrasound-guided continuous low anterior serratus plane block and N group underwent ultrasound-guided single anterior serratus plane block combined with rectus abdominis sheath block; the operation time, anesthesia time, incision length, sensory block time and sensory block maintenance time were counted and recorded. Pain score (NRS) was used to detect analgesia; alanine aminotransferase (ALT), liver function aspartate aminotransferase (AST), and prothrombin time (The time of thrombin, NRS) were measured by fluorescent quantitative PCR. （The time of thrombin (APTT), total bilirubin (TBIL) levels and adverse reactions.
Interventions
PROCEDUREUltrasound-guided continuous low serratus anterior plane block
Low anterior serratus plane block, move the mid-axillary line 4 and 5 intercostal puncture points are moved down and the puncture is changed to 7 and 8 intercostal.
PROCEDUREUltrasound-guided single serratus anterior plane block
Ultrasound-guided single anterior saw plane block was performed, and a needle was injected between the 4th and 5th costals in the midaxillary line.
Sponsors
Liu Di
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Age 18-60 years; 2. ASAI-II; 3. BMI: 18-29 kg/m2
Exclusion criteria
1. Combined cardiac, cerebral, hepatic, and renal failure; 2. Comorbid psychiatric and neuromuscular disorders; 3. A history of allergy to anesthetic drugs; 4. Participation in other recent clinical or drug trials.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Block plane | 30 minute after the surgery begins | The effect of anesthesia after ultrasound-guided nerve block was measured using planimetry, as well as the area being anesthetized. The chest wall between T2-T9 and ice cotton balls was used to assess the extent and extent of anesthesia block. |
| visual analogue scale | 24 hours after surgery | The visual analogue scale (VAS) of the patient's pain was recorded 24 hours after operation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patient satisfaction | 48 hours after surgery. | The patient's satisfaction with the analgesia 2 days after surgery was recorded. The analgesic effect: 1-3 as satisfactory, 4-6 as unsatisfactory, 7-10 as ineffective |
| Remedial analgesic drug | 24 hours after surgery. | Whether other analgesic drugs were added within 24 hours after operation was recorded |
| Intraoperative blood pressure changes | 2 hours after the beginning of surgery. | Blood pressure changes were measured directly by radial artery puncture and recorded. The changes in blood pressure and heart rate before and after excision and the use of intraoperative opioids. |
| Intraoperative heart rate changes | 2 hours after the beginning of surgery. | The curve of the change of the operative heart rate was recorded through the anesthesia machine. |
Countries
China
Contacts
Primary ContactJiang Fei
Outcome results
None listed