Hemophagocytic Lymphohistiocytoses
Conditions
Brief summary
Monocentric, observational, retrospective, no profit study aimed to analyze factors that are significantly impacting the outcome of patients diagnosed with HLH.
Detailed description
retrospective data collection to study: type of HLH familial vs secondary, sex, age, presence of infectious cause, involvement central nervous system ( SNC), hepatic involvement, presence of hemophagocytosis, presence of splenomegaly, presence of involvement of other organs, the value of neutrophils (PMN), the value of hemoglobin, platelets, albumin, triglycerides, ferritin, LDH, type of therapy and the response to therapy after 2 months
Interventions
OTHERObservation
Observation and retrospective data collection
Sponsors
Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
* Have received HLH diagnosis according to HLH 2004 criteria * age ⥶18 years. * followed at our facility between January 2004 and December 2021 * Whose parents have consented to participation and data processing
Exclusion criteria
* The study does not foresee specific
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| physiological parameter that are significantly impacting the outcome of patients diagnosed with HLH | through study completion, an average of 1 year | Type of HLH (familial vs secondary); sex (M or F); age (in year); presence of infectious cause; involvement central nervous system (yes or no); hepatic involvement (yes or no); presence of hemophagocytosis (yes or no); presence of splenomegaly (yes or no); involvement of other organs (yes or no); value of neutrophils (PMN, in 10\^9/L), hemoglobin (in g/dL), platelets (in 10\^9/L), albumin (in g/L), triglycerides (in mg/dL), ferritin (in UI/L) and LDH (in UI/L); |
Countries
Italy
Outcome results
None listed