Colorectal Cancer, Inflammatory Bowel Diseases, Precancerous Lesion
Conditions
Keywords
multi-omics study, adenoma, Inflammatory Bowel Disease
Brief summary
Colorectal cancer (CRC) has become one of the most common malignant tumors in the world, and the key to its prevention and control is early detection and treatment. As colorectal adenoma and inflammatory bowel disease (IBD) are the inevitable precursors of most CRC, screening for colorectal adenoma and IBD is of great importance for preventing CRC. The existing detection methods have high sensitivity for CRC, while limited in colorectal adenoma and IBD. Therefore, exploring a detection method with high sensitivity for colorectal adenoma and IBD is necessary. This project intends to use methylation detection technology, lactic acid modified omics, proteomics, metagenomics, and other omics technology, through the analysis of differences in feces and histological results in healthy volunteers, patients with non-advanced adenoma, patients with advanced adenomas, patients with IBD, and patients with CRC for early screening.
Interventions
None listed
Sponsors
Changhai Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients whose age is between 18-75. * Patients who have signed informed consent form.
Exclusion criteria
* Patients who have undergone colonic resection or polypectomy. * Patients with abnormal blood coagulation or taking antiplatelets or anticoagulants within 7 days. * Patients with hereditary colorectal cancer syndrome (including familial adenomatous polyposis). * Patients with pregnancy, severe chronic cardiopulmonary and renal disease. * Patients with failed cecal intubation. * Patients with poor BPQ necessitated a second bowel preparation. * Patients refusing to participate or to provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Detection of advanced colorectal adenoma | Through study completion, an average of 1 year | An advanced colorectal adenoma is defined as a colorectal adenoma ≥10 mm, adenoma with tubulovillous or villous histology, or adenoma with high-grade dysplasia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Detection of colorectal cancer | Through study completion, an average of 1 year | Lesions will be confirmed as malignant by histopathologic examination. |
| Detection of non-advanced colorectal adenoma | Through study completion, an average of 1 year | A non-advanced colorectal adenoma is defined as tubular adenoma less than 1cm in diameter. |
Countries
China
Contacts
Primary ContactZhaoshen Li, M.D
Backup ContactYu Bai, M.D
Outcome results
None listed