Effect of Hypocalcemia on the Outcome of Elderly Major Trauma Patients With Trauma-induced Coagulopathy

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05530161

Enrollment

371

Registered

2022-09-07

Start date

2015-01-01

Completion date

2023-09-01

Last updated

2022-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coagulopathy, Trauma

Keywords

trauma

Brief summary

Hypocalcaemia is an independent risk factor of TIC in elderly trauma patients. TIC combined with hypocalcemia had worse coagulation function and more serious acidosis.

Detailed description

This 5-year retrospective, observational, single-center study was conducted at the Second Affiliated Hospital of Zhejiang University Medical School (SAHZU, China). Elderly patients with trauma were registered when they were admitted into intensive care unit affiliated to department of Emergency medicine (EICU) since January 2015 and September 2020.The purpose of this study is to elucidate the effect of hypocalcemia on TIC in elderly trauma patients through a single-center retrospective study, so as to further optimize the diagnosis and treatment strategies for TIC in elderly trauma patients.

Interventions

OTHERhypocalcemia

hypocalcemia or normocalcemia

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to 100 Years

Healthy volunteers

Inclusion criteria

* age≥65 years old * history of trauma

Exclusion criteria

* previous anticoagulants or antiplatelet medication; * Coagulopathy caused by previous underlying diseases; * Blood products transfused before admission; * Cardiac arrest on admission; * Malignant tumor; * Data incomplete

Design outcomes

Primary

Measure	Time frame	Description
Internationalized Normalized Ratio (INR)	24 hour	coagulation function :Internationalized Normalized Ratio (INR)
Activated Partial Thromboplastin Time (APTT)	24 hour	coagulation function : Activated Partial Thromboplastin Time (APTT)
Prothrombin Time (PT)	24 hour	coagulation function : Prothrombin Time (PT)

Secondary

Measure	Time frame	Description
Blood products rate	through study completion, an average of 1 week	the rate of Blood products use

Countries

China

Contacts

Primary Contactyongan xu, doctor

xuyongan2000@163.com13757164833

Backup Contactyangbo kang, master

1179619719@qq.com19858878803

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026