Idiopathic Generalized Epilepsy
Conditions
Keywords
Attention, Epilepsy, Connectivity, EEG
Brief summary
Attentional disorders have been reported in neuropsychological studies evaluating patients suffering from generalized idiopathic epilepsy, but the data are disparate (in terms of test protocol). We aim to describe attentional and executive function disorder in IGE thanks to the Epitrack scale, validated in this specific population. Our secondary objective is to study the dynamic of cortical activity during an attentional task (the ANT), in order to describe the alteration of cortical networks in epileptic patients presenting with attentional disturbance.
Interventions
OTHERNeuropsychological screening and high resolution EEG recording
Each participant will be assessed with a battery of neuropsychological tests including Epitrack, the Raven's progressive matrice, the MoCA, the D2-R test, the BDI-II test, the STAI and the Qolie-31. Then, a prolonged EEG recording at rest and during an attentional task (the ANT) will be realized
Sponsors
University Hospital, Lille
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Idiopathic generalized epilepsy followed-up during at least 2 years * At least one antiepileptic drug medication * No cognitive decline (MoCA score \>26) * Absence of concomitant pathology that could interfere with the purpose of the study. * Be affiliated to the social security system * Have signed an informed consent
Exclusion criteria
* Pregnancy * Not able to give consent (Article 1121-8 of the CSP) Vulnerable person Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP) Have a high probability of not respecting the protocol or of abandoning the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Epitrack scale score | At 1 month after inclusion | EPITrack-Score shows the performance of attention and executive functions. Higher values indicate a better performance. scale from 9-49 (9 worst score - 49 best score) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Montreal Cognitive Assessment (MoCA) score | At 1 month after inclusion | Cognitive function was assessed by using MoCA score. Cognitive impairment was considered present when MoCA scores were \<26 . |
| D2-R test score | At 1 month after inclusion | cortical source connectivity patterns. |
| BDI-II score | At 1 month after inclusion | Anxiety-depressive symptoms score Beck Depressive Inventory Questionnaire (BDI-II) (score), higher scores mean worse outcome, value minimum of 0 maximum 63 |
| Raven's progressive matrice scores | At 1 month after inclusion | cortical source connectivity patterns. |
| quality of life using the Qolie-31 self questionnaire | At 1 month after inclusion | Quality Of Life In Epilepsy-Problems questionnaire (QOLIE31-P) questionnaire has been developed specifically to measure the quality of life of patients with epilepsy. The score ranges from 0 to 100 points. Higher scores reflect better quality of life; lower ones, worse quality of life. |
| High resolution Electro Encephalo Gram functional connectivity markers at rest and during the ANT task | At 1 month after inclusion | limited number of reproducible resting activity patterns, brain networks involved in the absence of task performance |
| STAI scale | At 1 month after inclusion | Anxiety-depressive symptoms score The State-Trait Anxiety Inventory (STAI) is a self-questionnaire, 20 questions, a score is calculated, ranging from 20 to 80, a high score indicating the presence of anxiety. |
Countries
France
Outcome results
None listed