Morbid Obesity, Acanthosis Nigricans, Insulin Resistance, Insulin Sensitivity, Bariatric Surgery Candidate
Conditions
Keywords
Acanthosis nigricans, Morbid obesity, Insulin secretion pattern, Prolactin, Sleeve gastrectomy
Brief summary
Acanthosis nigricans (AN) is increasing in its prevalence and is the most prevalent cutaneous manifestation in individuals with obesity. Insulin resistance or hyperinsulinemia is the main pathophysiological mechanism of obesity-related AN. However, the effect of laparoscopic sleeve gastrectomy (LSG) on insulin secretion pattern in Chinese morbidly obese patients with AN is unknown. In these study, the investigators aimed to explore the insulin secretion patterns in Chinese morbidly obese patients with Acanthosis nigricans (AN) and their alterations after LSG.
Interventions
PROCEDURELSG
LSG
Sponsors
Shen Qu
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* aged 18 to 65 years * BMI equal or greater than 35 kg/m2 * completed a 75-g OGTT and insulin release assay * eligible for the 12-month follow-up.
Exclusion criteria
* severe liver and renal dysfunction, preexisting heart disease, malignancy, or endocrine diseases such as pituitary adenoma and hypogonadism * mental illness * genetic disease * current or previous treatment that might affect the sex hormones and insulin secretion * gestation or lactation * loss to follow-up, or withdrawal from the study * unable to understand and comply with the study protocol.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Obesity | 2017-2023 | It was defined as BMI ≥ 28 kg/m2 according to the diagnostic criteria for obesity in a Chinese population. |
| A quantitative scale of Acanthosis Nigricans (AN) | 2017-2023 | 0-absent: not detectable on close inspection; 1-present: clearly present on close visual inspection, not visible to the casual observer, extent not measurable; 2-mild: limited to the base of the skull, does not extend to the lateral margins of the neck (usually \<3 inches in breadth); 3-moderate: extending to the lateral margins of the neck (posterior border of the sternocleidomastoid, usually 3-6 inches), should not be visible when the participant is viewed from the front; 4-severe: extending anteriorly (\>6 inches), visible when the participant is viewed from the front. |
| Insulin secretion patterns | 2017-2023 | they were derived from the peak time of insulin secretion during OGTT: Type I (peak time at 30 or 60 min) and Type II (peak time at 120 or 180 min). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Insulin sensitivity | 2017-2023 | It derived from the OGTT was estimated by the oral glucose insulin sensitivity (OGIS) index |
| BMI | 2017-2023 | It was calculated as weight (kg) divided by squared height (meters). |
| the disposition index (DI) | 2017-2023 | It was calculated as IGI/HOMA-IR. |
| Insulinogenic index (IGI) | 2017-2023 | It was calculated as :(insulin30min-insulin0min)/ (glucose30min-glucose0min). |
| a 2-h 75-g oral glucose tolerance test (OGTT) | 2017-2023 | It was performed after an overnight fasting in each patient pre- and 12 months pro-LSG, and blood samples were taken at 0, 30, 60, 120, and 180 min to determine the concentrations of plasma glucose and insulin. |
| HOMA-IR | 2017-2023 | It was calculated as FPG (mmol/L)×FINS (mU/L)/22.5 (24). |
Countries
China
Outcome results
None listed