Effect of Storage Condition on CD47 Expression Level in Platelet Concentrate

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05529394

Enrollment

Registered

2022-09-07

Start date

2022-12-20

Completion date

2025-12-31

Last updated

2022-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Platelet Storage Pool Deficiency

Brief summary

Effect of storage condition on CD47 expression level in platelet concentrate

Detailed description

CD47 is a cell surface glycoprotein expressed on all cell types .It is an attractive target for therapy because it is involved in regulation of cell survival and cell death by acting as a ligand for signal-regulatory protein alpha expressed on macrophages

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Inclusion criteria

* donors met AABB criteria

Exclusion criteria

* donors not met AABB criteria

Design outcomes

Primary

Measure	Time frame	Description
Assessment of CD47 expression level on platelets by exposure to different storage temperatures	3 years	To increase survival time of platelets

Outcome results